Evidence map›Paper›PMID 41585793›Full record

ReviewFrontiers in endocrinology2025

Unveiling the hidden: acquired pediatric hypothyroidism.

Mariacarolina Salerno, Donatella Capalbo, Mariella Valenzise, Raffaella Di Mase, Letteria Anna Morabito, Chiara Centonze, Malgorzata Gabriela Wasniewska

Erratum issuedAbstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Mariacarolina Salerno *Department of Translational Medical Sciences, Pediatric Endocrinology Unit, University of Naples Federico II, Naples, Italy.
Donatella Capalbo *Department of Translational Medical Sciences, Pediatric Endocrinology Unit, University of Naples Federico II, Naples, Italy.
Mariella ValenziseDepartment of Mother and Child, Pediatric Unit, University Hospital, Endo-ERN Center for Rare Endocrine Conditions, Messina, Italy.
Raffaella Di MaseDepartment of Mother and Child, Pediatric Endocrinology Unit, University Hospital Federico II, Endo-ERN Center for Rare Endocrine Conditions, Naples, Italy.
Letteria Anna MorabitoDepartment of Human Pathology of Adulthood and Childhood, Pediatric Unit, University of Messina, Messina, Italy, 6Medical Affairs, Merck Serono SpA, Rome, Italy.
Chiara CentonzeMedical Affairs, Merck Serono SpA, Rome, Italy.
Malgorzata Gabriela WasniewskaDepartment of Human Pathology of Adulthood and Childhood, Pediatric Unit, University of Messina, Messina, Italy, 6Medical Affairs, Merck Serono SpA, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acquired hypothyroidism is the most common thyroid disorder in children, with Hashimoto thyroiditis representing the leading cause in iodine-sufficient regions. Children and adolescents may present with a broad spectrum of clinical signs and symptoms, ranging in severity. Unusual or atypical presentations can complicate the differential diagnosis, potentially resulting in delays in both diagnosis and treatment, which may significantly impact growth and developmental outcomes. This review presents four real-life pediatric cases that illustrate both typical and atypical manifestations of acquired hypothyroidism. These cases are accompanied by a comprehensive overview of the condition's etiology, clinical presentation, diagnostic strategies, and management approaches in the pediatric population. The aim of this review is to summarize current knowledge on acquired hypothyroidism in children. By presenting real-world clinical cases, this review highlights key elements that can assist pediatricians in identifying and managing pediatric patients affected by this condition.

Indexed as

HypothyroidismAdolescentChildDiagnosis, DifferentialHashimoto DiseaseHumansacquired hypothyroidismcentral hypothyroidismHashimoto thyroiditisprimary hypothyroidismsubclinical hypothyroidism

Identifiers

PMID41585793
PMCPMC12828586

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.