ArticleFrontiers in endocrinology2025
1-hour post-load plasma glucose: a reliable marker of insulin resistance in type 2 diabetes, as determined by the TyG index.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigate the correlation between 1-hour postprandial glucose (1h-PG) and the triglyceride-glucose (TyG) index in type 2 diabetes mellitus (T2DM) subjects and to evaluate the predictive utility of 1h-PG for insulin resistance (IR). Research design and methods: Based on the criteria of 1h-PG ≥ 8.6mmol/L and 2h-PG ≥ 11.1mmol/L from the 125-gram standard steamed buns meal test, 1835 T2DM individuals were categorized as follows: Group 1: 1h-PG < 8.6mmol/L; Group 2: 1h-PG ≥ 8.6mmol/L and 2h-PG < 11.1mmol/L; Group 3: 1h-PG ≥ 8.6mmol/L and 2h-PG ≥ 11.1mmol/L. The severity of IR was assessed using the TyG index, with thresholds of > 8.81 for males and > 8.73 for females. Clinical and laboratory parameters, including glucose, C-peptide, insulin and lipid profiles were analyzed. Statistical analyses included Spearman's correlation, logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: 1h-PG exhibited a more pronounced positive correlation with the TyG index ( Conclusion: Among T2DM subjects, 1h-PG shows a stronger association with the TyG index than 2h-PG. These findings support the potential of 1h-PG as a more sensitive and cost-effective marker for early identification of insulin resistance, offering clinical utility in diabetes diagnosis and management.
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