ArticleFrontiers in nutrition2025
Elevated homocysteine levels predict impaired liver and renal function in women of reproductive age with polycystic ovary syndrome: a
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Polycystic ovary syndrome (PCOS) is associated with liver and kidney injury. Homocysteine (Hcy) may serve as a link between liver/kidney health and PCOS. This research aims to evaluate the relationship between serum Hcy levels and indicators of liver and renal function in women of reproductive age with PCOS. Methods: A post-hoc analysis of a randomized controlled trial is performed in this study. A total of 1,000 women diagnosed with PCOS were enrolled from secondary and tertiary hospitals in China. At baseline, we collected demographic information and measured metabolic factors, sex hormone levels, liver and renal function parameters, and Hcy levels. Women with an Hcy level >15 μmol/L were diagnosed with hyperhomocysteinemia (HHcy). Parameters associated with liver function were aspartate transferase (AST), alanine transferase (ALT), bilirubin, and total bile acid, while indicators of renal function were blood urea nitrogen (BUN), creatinine (CREA), cystatin C, and β2 microglobulin. Additionally, renal function was assessed using the glomerular filtration rate (eGFR). Results: Of the 938 PCOS women with available data, 149 (15.9%) were diagnosed with HHcy, while 789 (84.1%) had normal Hcy levels. Compared to the normal Hcy group, the HHcy group exhibited increased levels of AST (12.5 vs. 15.7, Conclusion: Elevated Hcy levels are significantly associated with indicators of impaired liver and renal function in women of reproductive age with PCOS.
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