ArticleFrontiers in nutrition2025
Impact of metabolic risk factors on colorectal cancer burden in China: a comprehensive analysis of trends from 1990 to 2021.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Review
- A study of factors influencing access to MDT among patients with stage III to stage IV colorectal cancer: a national multicenter survey.Frontiers in oncology · 2026Article
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Authors and funding
8 authors.
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Abstract
Background: Colorectal cancer (CRC) represents a significant public health challenge in China. With the rising prevalence of metabolic disorders such as obesity and diabetes, it is essential to understand the long-term burden of CRC attributable to metabolic risks. Methods: This study utilized data from the Global Burden of Disease (GBD) 2021 to estimate the burden of CRC attributable to metabolic risks in China from 1990 to 2021. Metrics analyzed included deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs), stratified by age, sex, and year. Joinpoint regression, age-period-cohort analysis, and decomposition methods were employed to explore temporal trends and underlying drivers. Results: In 2021, CRC attributable to metabolic risks caused 36,462 deaths and 902,557 DALYs in China, with significantly higher burdens among men. The age-standardized death and DALY rates were 2.36 and 56.09 per 100,000 in men, respectively, nearly double those in women. Between 1990 and 2021, age-standardized rates of mortality, DALYs, YLDs, and YLLs increased significantly (AAPC > 0; Conclusion: The burden of CRC attributable to metabolic risks has grown substantially in China, especially among men and older adults, with high BMI as the primary contributor. These findings highlight the urgent need for targeted prevention strategies addressing metabolic risk factors and sex-specific health interventions.
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