Evidence map›Paper›PMID 41586239›Full record

Trial reportFrontiers in nutrition2025

The beneficial impact of a low-carbohydrate diet on glycemic variability in insulin-deficient diabetes.

Jing Song, Jingjie Wang, Jing Wan, Ye Lu, Wenjie Wang, Li Li, Jun Wang, Li Wei, Jun Yin

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jing Song *Department of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.
Jingjie Wang *Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Jing WanDepartment of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.
Ye LuDepartment of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.
Wenjie WangDepartment of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.
Li LiDepartment of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.
Jun WangDepartment of Nutrition, Shanghai Eighth People's Hospital, Shanghai, China.
Li WeiDepartment of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.
Jun YinDepartment of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To evaluate the short-term metabolic effects of a low-carbohydrate diet (LCD) compared with a control diet (CON) in hospitalized patients with insulin-deficient diabetes, with particular focus on glycemic variability (GV). Methods: This non-randomized clinical trial included 359 inpatients with fasting C-peptide levels ≤1.0 ng/mL. Participants chose either an LCD or CON during hospitalization. GV was assessed using capillary and continuous glucose monitoring, with coefficient of variation (CV) as primary outcome. Secondary measures included other GV metrics, antidiabetic medication use, ketone levels, and adverse events. Subgroup analysis was conducted based on baseline C-peptide levels. Results: LCD led to a greater reduction in CV (diet-by-time interaction, Conclusion: Short-term LCD intervention improved GV in insulin-deficient diabetes, especially in patients with more significant Clinical trial registration: ChiCTR2000038006, https://www.chictr.org.cn/showproj.html?proj=60712.

Indexed as

continuous glucose monitoringC-peptideglycemic variabilityketone bodylow-carbohydrate diet

Identifiers

PMID41586239
PMCPMC12827080

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.