Evidence map›Paper›PMID 41586244›Full record

ArticleFrontiers in nutrition2025

The effects of a very low-energy ketogenic therapy on body composition, gut microbiota and metabolites in overweight subjects.

Yeganeh Manon Khazrai, Claudia Di Rosa, Annamaria Altomare, Marta Giovanetti, Ludovica Di Francesco, Greta Lattanzi, Chiara Spiezia, Antonella Simone, Federica Coccaro, Giulia Costa and 2 more

Abstract read
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In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yeganeh Manon Khazrai *Research Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Claudia Di Rosa *Research Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Annamaria AltomareDepartment of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Marta GiovanettiResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Ludovica Di FrancescoResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Greta LattanziResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Chiara SpieziaResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Antonella SimoneResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Federica CoccaroResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Giulia CostaResearch Unit of Food Science and Human Nutrition, Department of Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Rome, Italy.
Michele Pier Luca GuarinoOperative Research Unit of Gastroenterology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Silvia ManfriniUnit of Endocrinology and Diabetes, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is associated with chronic diseases and gut-brain axis disruptions, with diet influencing gut microbiota. This single-arm, uncontrolled study evaluated the effects of a 28 - day Very Low-Energy Ketogenic Therapy (VLEKT) on body weight, gut microbiota, and stool-derived metabolites in individuals with excess weight. Forty-one subjects underwent baseline (T0) assessment including anthropometry, bioimpedance analysis, gut microbiota profiling and completed FAST questionnaire before and after 28 days of VLEKT with meal replacements (T1). Follow-up was conducted at T1. Thirty-one participants completed the intervention (T1). Results showed significant reductions in body weight, BMI, and fat mass. Microbiota analysis revealed decreased Firmicutes and Actinobacteria, and increased Bacteroidetes and Verrucomicrobia. Genus-level changes included increases in

Indexed as

gut metabolitesketogenic dietmicrobiotaobesityVLEKT

Identifiers

PMID41586244
PMCPMC12828980

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.