Evidence map›Paper›PMID 41586300›Full record

ArticlePulmonary circulation2026

Knowledge Gaps and Controversies on Cardiopulmonary Exercise Testing in the Assessment of Pulmonary Vascular Disease: An Official Statement of the Pulmonary Vascular Research Institute Exercise and Right Ventricular Function Task Force.

Aaron B Waxman, Abraham Babu, Roberto Badagliacca, Eloara Ferreira, Patty George, Marco Guazzi, Luke Howard, Darlene Kim, Gabor Kovacs, Saad Kubba and 11 more

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Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Aaron B WaxmanDivision of Pulmonary and Critical Care Medicine, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Abraham BabuDepartment of Physiotherapy Manipal College of Health Professions Manipal Karnataka India.ORCID https://orcid.org/0000-0003-1084-0137
Roberto BadagliaccaDepartment of Cardiovascular and Respiratory Science Sapienza University of Rome Rome Italy.
Eloara FerreiraDivision of Respiratory Diseases, Department of Medicine Federal University of Sao Paulo Sao Paulo Brazil.ORCID https://orcid.org/0000-0002-3291-6473
Patty GeorgeDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine National Jewish Health Denver Colorado USA.ORCID https://orcid.org/0000-0002-6534-1020
Marco GuazziDepartment of Cardiology University of Milan Milan Italy.
Luke HowardNational Pulmonary Hypertension Service, Hammersmith Hospital, Imperial College Healthcare NHS Trust London UK.ORCID https://orcid.org/0000-0003-2822-210X
Darlene KimDivision of Cardiology, Department of Medicine National Jewish Health Denver Colorado USA.
Gabor KovacsDivison of Pulmonary Ludwig Boltzmann Institute for Lung Vascular Research, Medical University of Graz Graz Austria.
Saad KubbaDivision of Cardiology, Department of Medicine University of Arizona Tucson Arizona USA.
David LanglebenCenter for Pulmonary Vascular Disease, Azrieli Heart Center and Lady Davis Research Institute, Jewish General Hospital, McGill University Montreal Quebec Canada.
Colm McCabeDivision of Cardiology Royal Brompton Hospital London UK.
Thais MenezesDivision of Respiratory Diseases, Department of Medicine Federal University of Sao Paulo Sao Paulo Brazil.
Rudolf OliveiraDivision of Respiratory Diseases, Department of Medicine Federal University of Sao Paulo Sao Paulo Brazil.ORCID https://orcid.org/0000-0002-2252-8119
Stylianos Orfanos1st Department of Critical Care and Pulmonary Services National and Kapodistrian University of Athens Medical School and Pulmonary Hypertension Center, Evangelismos Hospital Athens Greece.
Inderjit SinghDivison of Pulmonary, Critical Care and Sleep Medicine Yale New Haven Hospital and Yale School of Medicine New Haven Connecticut USA.ORCID https://orcid.org/0000-0001-5624-1274
David SystromDivision of Pulmonary and Critical Care Medicine, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA.
Ryan TedfordDivsion of Cardiology, Department of Medicine Medical University of South Carolina Charleston South Carolina USA.ORCID https://orcid.org/0000-0001-9045-7722
Rebecca VanderpoolDivision of Cardiovascular Medicine Ohio State University Colombus Ohio USA.
Carmine Dario VizzaDepartment of Cardiovascular and Respiratory Science Sapienza University of Rome Rome Italy.
Franz P RischardDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine University of Arizona Tucson Arizona USA.ORCID https://orcid.org/0000-0002-6861-8304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise testing has long been essential for evaluating diagnosis, prognosis, and functional status in pulmonary hypertension (PH). Recent advances have clarified its role in defining reference values and prognostic markers. Nonetheless, substantial knowledge gaps persist regarding the implementation of invasive cardiopulmonary exercise testing (iCPET) and its potential to inform pathophysiology and therapeutic decision-making. This statement addresses the knowledge gaps that hinder the application of iCPET and exercise right heart catheterization (RHC) in the assessment of PH. We present research priorities and scenarios in which these tests may clarify drug mechanisms and support PH subphenotyping. An international, multidisciplinary task force of cardiology and pulmonology experts reviewed the literature and formulated consensus recommendations through iterative discussions.

Indexed as

cardiopulmonary exercise testingphenotypingpulmonary hypertensionpulmonary vascular diseaserisk stratification

Identifiers

PMID41586300
PMCPMC12824459

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.