Evidence map›Paper›PMID 41586506›Full record

ArticleInfection and immunity2026

Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl/MAPK pathway.

Shu-Jun Ma, Ke-Fang Xie, Jie-Lin Duan, Xian-Long Wang, Yi-Heng Yang, Ying Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shu-Jun Ma *Department of Dermatology, The First Affiliated Hospital of Naval Military Medical University, Shanghai, China.
Ke-Fang Xie *Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0009-5533-6373
Jie-Lin Duan *Department of Respiratory and Critical Care Medicine, Institute of Respiratory Medicine, Dongguan Key Laboratory of Immune Inflammation and Metabolism, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China.
Xian-Long WangClinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yi-Heng YangClinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0009-0007-4687-1775
Ying WangDepartment of Dermatology, The First Affiliated Hospital of Naval Military Medical University, Shanghai, China.ORCID 0009-0000-3353-906X

Funding

National Natural Science Foundation of China 82201929Natural Science Foundation of Shanghai 25ZR1402509
6 · The paper itself

Abstract

Non-receptor tyrosine kinase c-Abl is critical for host defense against bacterial and viral infections, yet its role in antifungal immunity remains elusive. Here, we report that inhibition of c-Abl with flumatinib mesylate significantly impairs the survival rate and exacerbates fungal burden in mice infected with

Indexed as

Candida albicansCandidiasisImmunity, InnateLectins, C-TypeMAP Kinase Signaling SystemProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-cblAnimalsDendritic CellsMiceMice, Inbred C57BLSignal TransductionCbl protein, mouseLectins, C-TypeProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-cblantifungal immunityc-AblC. albicansc-CblMAPKs

Identifiers

PMID41586506
PMCPMC12974120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.