Evidence map›Paper›PMID 41586832›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

The in vivo disposition of mildronate and its regulatory effects on L-carnitine in rats.

Qiannan Zhang, Junwen Hu, Chuyao Yang, Jingtao Wang, Xia Wu, Lingchao Wang, Wenpeng Zhang, Xiaomei Zhuang

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiannan ZhangAcademy of Military Medical Sciences, Beijing, 100850, China.
Junwen HuAcademy of Military Medical Sciences, Beijing, 100850, China.
Chuyao YangAcademy of Military Medical Sciences, Beijing, 100850, China.
Jingtao WangAcademy of Military Medical Sciences, Beijing, 100850, China.
Xia WuAcademy of Military Medical Sciences, Beijing, 100850, China.
Lingchao WangAcademy of Military Medical Sciences, Beijing, 100850, China.
Wenpeng ZhangAcademy of Military Medical Sciences, Beijing, 100850, China.
Xiaomei ZhuangAcademy of Military Medical Sciences, Beijing, 100850, China. xiaomeizhuang@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop an LC-MS/MS method for simultaneous quantification of mildronate and L-carnitine, and to investigate the pharmacokinetic profile of mildronate in rats, its effect on L-carnitine homeostasis, as well as the exposure characteristics, underlying mechanisms, and their associations with therapeutic efficacy and toxicity risks. We quantified mildronate using its deuterated analog ([

Indexed as

CarnitineMethylhydrazinesAdministration, OralAnimalsChromatography, LiquidDose-Response Relationship, DrugLiquid Chromatography-Mass SpectrometryMaleMuscle, SkeletalMyocardiumRatsRats, Sprague-DawleyTandem Mass SpectrometryTissue Distribution3-(2,2,2-trimethylhydrazine)propionateCarnitineMethylhydrazinesL-carnitineMildronateMyocardial-targeted distributionNonlinear pharmacokinetics

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.