Evidence map›Paper›PMID 41586869›Full record

ReviewIn vitro cellular & developmental biology. Animal2026

Exploring the potential of RNA interference (RNAi) in mosquito control: from mechanisms to molecular insights.

Sundararajan Balasubramani, Surjeet Kumar Arya, Gayathiri Ekambaram, Dhandapani Gurusamy, Saravanamoorthy Mutharasanallur Duraisamy

Abstract readReview
PubMed Publisher
In one paragraph

Review in In vitro cellular & developmental biology. Animal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sundararajan Balasubramani *Department of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, 40546, USA. sundarpbt87@gmail.com.
Surjeet Kumar Arya *Department of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, 40546, USA. surjeetarya95@gmail.com.
Gayathiri EkambaramDepartment of Plant Biology and Plant Biotechnology, Guru Nanak College (Autonomous), Chennai, 600042, Tamil Nadu, India.
Dhandapani GurusamyDepartment of Botany, Kongunadu Arts and Science College (Autonomous), Bharathiar University, Coimbatore, 641029, Tamil Nadu, India.
Saravanamoorthy Mutharasanallur DuraisamyDepartment of Botany, Thanthai Periyar Government Arts and Science College, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mosquito-borne diseases represent a growing global health crisis, exacerbated by climate change and insecticide resistance. RNA interference (RNAi), a natural mechanism of gene silencing, offers a promising, target-specific alternative for mosquito control. This review explores the potential of RNAi to disrupt critical physiological processes, such as reproduction and disease transmission, thereby reducing vector populations and competence. We examine the mechanisms of RNAi, its application in combatting insecticide resistance, and recent advancements in delivery systems, including nanobody- and chitosan-based nanoparticles, which enhance the stability and uptake of double-stranded RNA (dsRNA) molecules. However, significant challenges remain, such as optimizing field-effective delivery methods and assessing potential off-target effects on non-target organisms. Continued innovation in RNAi technology is pivotal for developing sustainable and environmentally sound vector control strategies. This review synthesizes current research, highlighting the molecular insights, practical applications, and future directions for integrating RNAi into modern public health initiatives.

Indexed as

CulicidaeMosquito ControlRNA InterferenceAnimalsInsecticide ResistanceMosquito VectorsBiomarkerEnvironmental issueGene silencingGenomicsInsecticide resistanceMosquitoPublic healthRNA interferenceSustainable practicesVector control

Identifiers

PMID41586869

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.