Evidence map›Paper›PMID 41587116›Full record

ArticleJournal of chemical information and modeling2026

Binding Site Vectors Enable Mapping of Cytochrome P450 Functional Landscapes.

Tea Kuvek, Zuzana Jandová, Klaus-Juergen Schleifer, Chris Oostenbrink

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tea KuvekInstitute for Molecular Modeling and Simulation, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0001-5030-2275
Zuzana JandováBoehringer Ingelheim International GmbH, Dr.-Boehringer-Gasse 5-11, 1121 Vienna, Austria.
Klaus-Juergen SchleiferBASF SE, Carl-Bosch-Strasse 38, 67056 Ludwigshafen, Germany.ORCID 0000-0003-3428-1384
Chris OostenbrinkInstitute for Molecular Modeling and Simulation, BOKU University, Muthgasse 18, 1190 Vienna, Austria.ORCID 0000-0002-4232-2556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding similarities between protein binding sites has long been of great interest, as such comparisons can reveal functional relationships that transcend sequence or fold. However, systematic comparison remains challenging due to the difficulty of defining active sites consistently and developing descriptors that are both general and discriminative. We present

Indexed as

Cytochrome P-450 Enzyme SystemBinding SitesHumansMolecular Dynamics SimulationProtein ConformationStatic ElectricityCytochrome P-450 Enzyme System

Identifiers

PMID41587116
PMCPMC12892331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.