Evidence map›Paper›PMID 41588170›Full record

ArticleNature2026

Scalable and multiplexed recorders of gene regulation dynamics across weeks.

Lirong Zheng, Dongqing Shi, Yixiao Yan, Bingxin Zhou, Jormay Lim, Yongjie Hou, Bobae An, Jason K Adhinarta, Michael Lin, BumJin Ko and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Lirong Zheng *Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6803-5048
Dongqing Shi *Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8687-2701
Yixiao Yan *Department of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Bingxin ZhouDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3897-9766
Jormay LimDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Yongjie HouDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Bobae AnMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jason K AdhinartaDepartment of Computer Science, Boston College, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6247-7475
Michael LinDepartment of Computer Science, Boston College, Boston, MA, USA.
BumJin KoNash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
William C JoestenDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.
Mehul GautamDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0009-9076-770X
Elie D M HuezKresge Hearing Research Institute and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-0696-564X
Eung Chang KimMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Emily G KlyderDepartment of Chemistry, University of Michigan, Ann Arbor, MI, USA.
Boxuan ChangDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA.
Sethuramasundaram PitchiayaDepartment of Urology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-2529-5186
Michael T RobertsKresge Hearing Research Institute and Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-2835-8752
Denise J CaiNash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7729-0523
Edward S BoydenMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Donglai WeiDepartment of Computer Science, Boston College, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2329-5484
Pietro LiòDepartment of Computer Science and Technology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-0540-5053
Changyang LinghuDepartment of Cell and Developmental Biology, Medical School, University of Michigan, Ann Arbor, MI, USA. linghu@umich.edu.ORCID http://orcid.org/0000-0002-7481-5275

Funding

Multidimensional Optimization of Voltage Indicators for In Vivo Neural Activity ImagingR01MH122971 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Xue Han · 2022 to 2024
$2.0M
Expansion MicroscopyR01EB024261 · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2025 to 2025
$607k
Early Stage Training in the NeurosciencesT32NS076401 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$268k
NIBIB NIH HHS R01 EB024261NIMH NIH HHS R01 MH122971NINDS NIH HHS T32 NS076401
6 · The paper itself

Abstract

Gene expression is dynamically controlled by gene regulatory networks comprising multiple regulatory components to mediate cellular functions

Indexed as

Gene Expression RegulationSingle-Cell AnalysisAnimalsBrainDoxycyclineFemaleGene Regulatory NetworksGenes, Immediate-EarlyHumansMicePromoter Regions, GeneticSpatio-Temporal AnalysisTime FactorsTranscription FactorsTranscription, GeneticDoxycyclineTranscription Factors

Identifiers

PMID41588170
PMCPMC13102694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.