MALT1 Knockdown Alleviates Multiorgan Injury and Inflammation Through Inhibiting TAK1/NF-κB Signaling Pathway-Mediated T-Helper 1 and 17 Differentiations in LPS-induced Inflammation.

Qinghe Huang, Yan Luo, Qinggui Chen, Yan Cui

Abstract read

In one paragraph

Article in Inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qinghe HuangDepartment of General ICU, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, 361004, China.

Yan LuoDepartment of General ICU, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, 361004, China.

Qinggui ChenDepartment of General Surgery, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, 361004, China.

Yan CuiDepartment of Orthopaedic Trauma, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, No.201-209 South Hubin Road, 361004, Xiamen, China. caiya698@163.com.

Funding

2022 Xiamen Medical and Health Guidance Project No. 3502Z20224ZD10572024 Provincial Natural Science Foundation of Joint Funding Project No. 2024J01133422024 Xiamen Medical and Health Key Project No. 3502Z20244004

6 · The paper itself

Abstract

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a vital regulator of inflammation and innate immune response. The aim of this study was to evaluate the potential of MALT1 knockdown for attenuating lipopolysaccharide (LPS)-induced inflammation. C57BL/6 mice received tail vein injection of knockdown control or Malt1 shRNA, followed by intraperitoneal injection of LPS two weeks later. After 24 h of LPS injection, the mice were euthanized for further analysis. The peripheral naïve CD4

Indexed as

InflammationMAP Kinase Kinase KinasesMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinNF-kappa BTh17 CellsTh1 CellsAnimalsCell DifferentiationCytokinesGene Knockdown TechniquesLipopolysaccharidesMaleMAP Kinase Kinase Kinase 7MiceMice, Inbred C57BLSignal TransductionCytokinesLipopolysaccharidesMalt1 protein, mouseMAP Kinase Kinase Kinase 7MAP Kinase Kinase KinasesMucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinNF-kappa BTranscription Factor RelALPS-induced inflammationMALT1Organ injuryTAK1/NF-κBT-helper cells

Identifiers

PMID41588174

DOI10.1007/s10753-025-02447-6

PMCPMC12894189

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.