ArticleScientific reports2026
Multimodal magnetic resonance imaging of the vastus medialis for quantitative diagnosis and grading in early-stage knee osteoarthritis and its correlation with severity.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Early-stage knee osteoarthritis (EKOA) requires timely diagnosis. The recent diagnostic criteria for EKOA by the bone and joint branch of the Chinese geriatric care association remain limited. These limitations necessitate the development of novel, clinical non-invasive imaging modalities to quantitatively evaluate knee joint structures and improve diagnostic accuracy in EKOA. We aimed to investigate whether the quantitative parameters of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and fat analysis calculation technique (FACT) may differentiate between patients with EKOA and healthy controls, as well as evaluate the correlations of the parameters with X-ray Kellgren–Lawrence (KL) grading and Visual Analog Scale (VAS). We analyzed 207 knee joints of 168 participants, including 62 from healthy controls (control group) and 145 from patients with EKOA (observation group: excluding those with other combined knee joint diseases or underlying diseases); the observation group was categorized into three subgroups based on the KL grading system. Age and body mass index (BMI) exhibited no significant differences between the two groups. Although age and BMI showed slight variations across the KL subgroups, the differences were not statistically significant. IVIM-DWI (diffusion coefficient [D], pseudo-diffusion coefficient [D*], and perfusion fraction [f]) and FACT (fat fraction [FF]) parameters were acquired in the vastus medialis using a 3.0T magnetic resonance imaging (MRI) scanner. Intergroup comparisons of IVIM-DWI and FACT parameters were conducted, and subgroup differences and correlation between the IVIM-DWI and FACT parameters and radiographic KL grades were assessed. The observation group showed higher D, D*, and FF values than did the control group; however, the f values were lower in the observation group. Within the observation group, Grade II knees had higher D and FF values than did Grade 0 and I knees, as well as lower f values than did Grade 0 knees. D and FF values showed a moderately positive correlation with both KL grades and VAS scores, whereas f values showed a weak negative correlation with both. IVIM-DWI and FACT may provide biological information of improved sensitivity and accuracy for the quantitative diagnosis of EKOA at the microstructural level in the vastus medialis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.