ArticleNature cancer2026
Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study.
Registry-linked trialAbstract read
In one paragraph
Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05926102 (The Prostate Cancer, Genetic Risk, and Equitable Screening Study), which is not on this map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS): A Pragmatic Trial of Precision Prostate Cancer Screening
Who cites it
4 citing papers in PubMed.
- Development and pilot testing of a prostate cancer polygenic risk report.BMC medical genomics · 2026Trial
- AI-based multimodal integration of genomics and electronic health records.Nature reviews. Genetics · 2026Review
- Prostate-Specific Antigen Screening Patterns and Metastatic Prostate Cancer in US Veterans.JAMA network open · 2026Article
- Germline polygenic score for prostate cancer aggressiveness.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
69 authors.
Jason L Vassy *VA Boston Healthcare System, Boston, MA, USA. jvassy@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6113-5564
Anna M Dornisch *Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0009-0007-2602-7323
Roshan KarunamuniDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Michael GatzenBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5390-0705
Christopher J KachulisBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2095-7419
Niall J LennonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2874-7371
Charles A BrunetteVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1620-3526
Morgan E DanowskiVA Boston Healthcare System, Boston, MA, USA.
Richard L HaugerCenter of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-1509-1868
Isla P GarrawayDivision of Urology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Adam S KibelUrology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kyung M LeeVA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8995-0448
Julie A LynchVA Informatics and Computing Infrastructure, VA Salt Lake City Healthcare System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0108-2127
Kara N MaxwellCorporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8192-4202
Dmitry RatnerVA Boston Healthcare System, Boston, MA, USA.
Brent S RoseDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Craig C TeerlinkVA Salt Lake City Healthcare System, Salt Lake City, UT, USA.
George J XuDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Sean E HofherrBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Katherine A LaffertyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Katie LarkinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Edyta MalolepszaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Candace J PattersonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Diana M ToledoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jenny L DonovanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6488-5472
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Richard M MartinPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-7992-7719
David E NealNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Emma L TurnerPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Ole A AndreassenCentre for Precision Psychiatry and KG Jebsen Centre for Neurodevelopment, Oslo University Hospital and University of Oslo, Oslo, Norway.
Anders M DaleNORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.
Ian G MillsNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Aswin AbrahamDepartment of Oncology, Cross Cancer Institute, University of Alberta, Alberta, Canada.
Jyotsna BatraSchool of Biomedicine, Faculty of Health and Medical Sciences, Bond University, Gold Coast, Queensland, Australia.ORCID http://orcid.org/0000-0003-4646-6247
Judith ClementsCentre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-6026-1964
Olivier CussenotSorbonne Université, Paris, France.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Rosalind A EelesThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-3698-6241
Jay H FowkeDivision of Epidemiology, Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3803-8162
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1073-2753
Robert J HamiltonDept. of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Jasmine LimDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Yong-Jie LuCentre for Cancer Biomarker and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-6174-6621
Robert J MacInnisCancer Epidemiology Division, Cancer Council Victoria, East Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-1627-5047
Christiane MaierZentrum für Humangenetik Tuebingen, Tuebingen, Germany.
Lorelei A MucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Luc MultignerUniv Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France.ORCID http://orcid.org/0000-0003-3205-8568
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0001-5053-0390
Sune F NielsenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Marie-Élise ParentEpidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, Quebec, Canada.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-6384-6447
Gyorgy PetrovicsUniformed Services University, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3732-284X
Anna PlymDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6351-4744
Azad RazackDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Barry S RosensteinDepartment of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Johanna SchleutkerInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0002-1863-0305
Karina Dalsgaard SørensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark.ORCID http://orcid.org/0000-0002-4902-5490
Paul A TownsendDivision of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-8956-9508
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9571-0763
Ana VegaFundación Pública Galega Medicina Xenómica, Santiago de Compostela, Spain.ORCID http://orcid.org/0000-0002-7416-5137
Catharine M L WestDivision of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.ORCID http://orcid.org/0000-0002-0839-3449
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4623-0544
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Profile Steering Committee
IMPACT Study Steering Committee and Collaborators
PRACTICAL Consortium
VA Million Veteran Program
Tyler M SeibertDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. tseibert@health.ucsd.edu.ORCID http://orcid.org/0000-0002-4089-7399
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MAlbert Einstein Cancer Center (AECC) PRYES211091VEGACSRD VA I01 CX002635NCI NIH HHS P30 CA008748U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01CX002635
Abstract
Precision healthcare aims to tailor disease prevention and early detection to individual risk. Prostate cancer screening may benefit from genomics-informed approaches. We developed and validated the P-CARE model, a prostate cancer risk prediction tool combining a polygenic score, family history and genetic ancestry, using data from over 585,000 male participants in the Million Veteran Program. The model was externally validated in diverse cohorts and implemented via a blended genome-exome assay for clinical use. Here we show that the P-CARE model identifies clinically meaningful gradients of prostate cancer risk among men, with higher scores associated with increased risk of any, metastatic and fatal prostate cancer. The model is now being used in a clinical trial of precision prostate cancer screening. This work demonstrates the potential for genomics-enabled health systems to improve prostate cancer screening and prevention in men. ClinicalTrials.gov registration: NCT05926102 .
Indexed as
Early Detection of CancerGenomicsPrecision MedicineProstatic NeoplasmsAgedGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedRisk AssessmentRisk Factors
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
NCT05926102ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.