Evidence map›Paper›PMID 41588420›Full record

ArticleBiology of sex differences2026

Sex-specific difference on anxiety- and depressive-like behavior in neuronal growth regulator 1-knockout mice.

So Rok Lee, Eunji Yoon, Sooyeon Baek, Jin Gyeom Kim, Jong-Oh Kim, Su-In Yoon, Soojin Lee, Jin Ah Cho

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In one paragraph

Article in Biology of sex differences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

So Rok LeeDepartment of Food and Nutrition, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea.
Eunji YoonResearch Center for Microbiome-Brain Disorders, Chungnam National University, Daejeon, 34134, South Korea.
Sooyeon BaekDepartment of Food and Nutrition, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea.
Jin Gyeom KimDepartment of Food and Nutrition, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea.
Jong-Oh KimDepartment of Sport Science, Hannam University, Daejeon, 34430, South Korea.
Su-In YoonDepartment of Food and Nutrition, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea.
Soojin LeeDepartment of Microbiology and Molecular Biology, Chungnam National University, Daejeon, 34134, Korea.
Jin Ah ChoDepartment of Food and Nutrition, Chungnam National University, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea. jacho@cnu.ac.kr.

Funding

Korean National Institute of Health 2025-ER1104-00National Research Foundation of Korea RS-2020-NR049567National Research Foundation of Korea RS-2020-NR049567, RS-2022-NR069880National Research Foundation of Korea RS-2022-NR069880
6 · The paper itself

Abstract

backgroundSex differences are evident in anxiety and depression, and women more frequently present with comorbid anxiety and depression alongside gastrointestinal disturbances. This pattern suggests contributions from sex-specific biological mechanisms and gut-brain communication. Negr1, a molecule regulating neuronal growth and connectivity, has been linked to depression-relevant behaviors in animal models. However, its mechanisms and potential sex-specific effects remain unclear.

methodsBehavioral tests were used to assess phenotypes related to depression, anxiety, and learning in male and female wild-type (WT) and Negr1

resultNegr1

conclusionsThis study demonstrates that, in Negr1

Indexed as

AnxietyDepressionSex CharacteristicsAnimalsApoptosisBehavior, AnimalBrainBrain-Derived Neurotrophic FactorEndoplasmic Reticulum StressFemaleMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutBrain-Derived Neurotrophic FactorAnxietyApoptosisDepressionER stressGut–brain axisNegr1Sex differences

Identifiers

PMID41588420
PMCPMC12918530

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.