ReviewJournal of nanobiotechnology2026
Emerging potential of engineered nanozymes in periodontitis treatment: from monotherapy to hierarchical therapy.
Review in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Multi-Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Ultrasound-activated nanoregulator enables CuJournal of nanobiotechnology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The unique pathological microenvironment of periodontitis poses significant challenges to conventional therapies and drives the development of advanced treatment strategies. Engineered nanozymes as multifunctional nanomaterials offer promising alternatives for actively modulating disease microenvironments. Compared with traditional nanozymes, engineered nanozymes are rationally designed through elemental doping, heterojunction construction, and surface modification, leading to increased catalytic efficiency, microenvironmental responsiveness, and multifunctional integration. This review systematically discusses three representative engineering strategies for the treatment of periodontitis: antibacterial, anti-inflammatory, and regenerative approaches. Furthermore, we introduce the concept of "hierarchical therapy," which integrates these strategies into a unified framework for achieving more precise and effective therapeutic outcomes. Finally, this review highlights the current challenges faced by engineered nanozymes, including biosafety concerns, catalytic durability, and barriers to clinical translation. Overall, this study aimed to provide a comprehensive overview of the rational design, functional integration, and therapeutic potential of engineered nanozymes in periodontal applications, offering valuable guidance for the development of intelligent nanoplatforms for future precision oral medicine.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.