Evidence map›Paper›PMID 41588488›Full record

ArticleBMC cancer2026

Predicting central lymph node metastasis in papillary thyroid carcinoma using a fusion model of vision transformer and traditional radiomics based on dynamic dual-modality ultrasound.

Peng-Fei Zhu, Xiao-Feng Zhang, Yu-Xiang Mao, Pu Zhou, Jian-Jun Lin, Long Shi, Xin-Wu Cui, Ying He

Abstract read
In one paragraph

Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peng-Fei Zhu *Department of Ultrasonic Medicine, Nantong Tumor Hospital, Nantong, Jiangsu, China.
Xiao-Feng Zhang *Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yu-Xiang MaoDepartment of Ultrasonic Medicine, Nantong Tumor Hospital, Nantong, Jiangsu, China.
Pu ZhouDepartment of Ultrasonic Medicine, Nantong Tumor Hospital, Nantong, Jiangsu, China.
Jian-Jun LinDepartment of Medical Ultrasound, The First People's Hospital of Qinzhou, Guangxi Zhuang Autonomous Region, Qinzhou, China.
Long ShiDepartment of Ultrasonic Medicine, Jingmen Second People's Hospital, Jingmen, Hubei, China.
Xin-Wu CuiDepartment of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. cuixinwu@live.cn.
Ying HeDepartment of Ultrasonic Medicine, Nantong Tumor Hospital, Nantong, Jiangsu, China. 123heying456@sina.com.

Funding

Jingmen Science and Technology Bureau 2022YFZD012
6 · The paper itself

Abstract

objectiveThis study aimed to develop a novel fusion model based on dynamic dual-modality with B-mode ultrasound and superb microvascular imaging (SMI), combining Vision Transformer (ViT) and radiomics features to predict central lymph node metastasis (CLNM) in thyroid cancer patients.

methodIn this retrospective diagnostic study, 310 patients with pathologically confirmed papillary thyroid carcinoma from two hospitals were included. We trained ViT models for B-mode and SMI, then extracted ViT and radiomics features from their video images. Initially, Single-modality models were developed, including the B-mode radiomics model (BMUS_RAD) and the B-mode ViT model (BMUS_ViT). Subsequently, Dual-modality models were constructed, encompassing the Dual-modality radiomics model (DMU_RAD), the Dual-modality ViT model (DMU_ViT), and finally, the integrated model DMU_RAD_ViT, to enhance the prediction of CLNM. The performance of each model was compared, and SHAP was utilized for the visual interpretation of the novel fusion model.

resultsAmong all the models, the fusion model DMU_RAD_ViT performed the best (AUC = 0.901, p < 0.05). At the same time, the dual-modality model DMU_RAD(AUC = 0.856) and DMU_ViT(AUC = 0.832) is also higher than the single-modal model BMUS_RAD (AUC = 0.837) and BMUS_ViT (AUC = 0.789), respectively. SHAP analysis revealed that 16 radiomics and ViT features from both modalities contributed to the DMU_RAD_ViT model.

conclusionsThe Dual-modality fusion model, integrating both radiomics and ViT features, can be utilized to predict CLNM.

Indexed as

Lymphatic MetastasisThyroid Cancer, PapillaryThyroid NeoplasmsAdultFemaleHumansLymph NodesMaleMiddle AgedRadiomicsRetrospective StudiesUltrasonographyCentral lymph node metastasisDynamic ultrasoundPapillary thyroid carcinomaSuperb microvascular imagingVision transformer

Identifiers

PMID41588488
PMCPMC12917971

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.