ArticleMolecular nutrition & food research2026
Lycopene's Role in Mitigating Obesity-Induced Cardiac Remodeling: Insights Into Inflammatory and MMP-2 Pathways.
Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lycopene's Role in Mitigating Obesity-Induced Cardiac Remodeling: Insights Into Inflammatory and MMP-2 Pathways.Molecular nutrition & food research · 2026Article
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Authors and funding
16 authors.
Funding
Abstract
Obesity, characterized by chronic low-grade inflammation, promotes cardiac structural and functional abnormalities. This study evaluated the therapeutic potential of lycopene in attenuating obesity-induced cardiac remodeling, based on its antioxidant and anti-inflammatory properties and its ability to inhibit matrix metalloproteinase-2 (MMP-2) activation, thereby preserving myocardial collagen integrity. Male Wistar rats were fed a high-sugar, high-fat (HSF) diet to induce obesity and cardiac remodeling. After the onset of cardiac dysfunction, animals received lycopene supplementation (10 mg/kg/day) for 10 weeks. The HSF diet caused metabolic disturbances, including hypertension, increased adiposity, and insulin resistance, accompanied by myocardial remodeling, inflammation, and elevated MMP-2 activity. Lycopene supplementation reversed insulin resistance, mitigated myocardial remodeling, and improved both systolic and diastolic cardiac function. It also reduced inflammatory markers (TNF-α, IL-6, NF-κB, TLR-4), decreased MMP-2 activation, and enhanced TIMP-2 and type I collagen expression. Lycopene demonstrated cardioprotective and anti-inflammatory effects in obesity-induced cardiac remodeling. By targeting inflammation and extracellular matrix degradation, lycopene may serve as an effective adjunctive therapeutic approach for preventing or treating obesity-related cardiac disorders.
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Registered trials
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