Evidence mapPaperPMID 41589204Full record

ReviewHepatology forum2026

MASLD and viral hepatitis overlap: An emerging dual burden in chronic liver disease.

Maham Ejaz, Kirsh Kumar, Daniyal Sohail, Imteshal Sarfaraz, Hafsa Azam, Fatima Yaseen

Abstract readReview
In one paragraph

Review in Hepatology forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maham EjazDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Kirsh KumarDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Daniyal SohailDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Imteshal SarfarazDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Hafsa AzamDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Fatima YaseenDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coexistence of metabolic dysfunction-associated steatotic liver disease (MASLD) and viral hepatitis has gained greater focus due to the global increase in chronic liver diseases. This convergence of conditions creates a unique clinical entity characterized by complex molecular interactions, difficult diagnosis, and treatment issues. The frequency of MASLD alongside viral hepatitis is becoming more prevalent. Overlapping pathogenic mechanisms, such as insulin resistance, activation of pro-inflammatory cytokines, hepatic steatosis, and persistent viral infection, establish a synergistic pathophysiological relationship that exacerbates fibrosis and liver damage. Non-invasive fibrosis assessments, multimodal imaging, and, in certain cases, liver biopsies are often required to achieve diagnostic accuracy. This review intends to examine the epidemiological overlap, shared pathophysiological mechanisms, diagnostic hurdles, and management challenges associated with the concurrent manifestation of MASLD and viral hepatitis.

Indexed as

Coinfectionhepatitis Bhepatitis Chepatocellular carcinomaliver fibrosisMASLDviral hepatitis

Identifiers

PMID41589204
PMCPMC12831982

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.