Evidence map›Paper›PMID 41589260›Full record

ArticleActa radiologica open2026

The effect of age and sex on T1, T2, and T2* relaxation time constants in cardiac MRI in healthy Finnish population.

Mimmi K Liukkonen, Miska Jämsä, Suvi Hartikainen, Minna Husso, Marja Hedman, Heikki Hietanen, Martin Ugander, Saara Sillanmäki, Elias Ylä-Herttuala

Abstract read
In one paragraph

Article in Acta radiologica open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mimmi K LiukkonenClinical Imaging Centre, Kuopio University Hospital, Kuopio, Finland.ORCID https://orcid.org/0000-0002-4634-6803
Miska JämsäSchool of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Suvi HartikainenClinical Imaging Centre, Kuopio University Hospital, Kuopio, Finland.ORCID https://orcid.org/0000-0001-7718-5144
Minna HussoSchool of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Marja HedmanClinical Imaging Centre, Kuopio University Hospital, Kuopio, Finland.
Heikki HietanenClinical Imaging Centre, Kuopio University Hospital, Kuopio, Finland.
Martin UganderDepartment of Clinical Physiology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Saara SillanmäkiClinical Imaging Centre, Kuopio University Hospital, Kuopio, Finland.
Elias Ylä-HerttualaClinical Imaging Centre, Kuopio University Hospital, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Magnetic resonance imaging (MRI) enables the non-invasive assessment of myocardial tissue properties through the T1, T2, and T2* relaxation mapping. Establishing population-specific normal reference values enhances diagnostic accuracy. Purpose: To study the effect of sex and age on the T1, T2, and T2* relaxation time constants in a healthy Finnish population. Methods: We recruited 47 healthy volunteers aged 18-60 years from Eastern Finland from 2023 to 2024 and categorised them by sex and age (18-30 years, 31-41 years, and 42-60 years). The participants underwent a comprehensive screening process to eliminate the possibility of cardiac disease. MRI scans were conducted on 40 participants at 1.5 T. The T1, T2, and T2* relaxation time constants were calculated for basal, mid-ventricular, and apical short-axis slices. Results: The T1 and T2 relaxation time constants were higher in females than males (T1: 1040 ± 29 vs 1020 ± 17 ms, Conclusion: This study established age-independent and sex-specific reference values for the native myocardial T1, T2, and T2* relaxation time constants at 1.5 T. Females had higher T1 and T2 values than males, and age did not affect these values.

Indexed as

Magnetic resonance imagingsex-related differencesT1T2T2*tissue characterisation

Identifiers

PMID41589260
PMCPMC12831919

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.