ReviewThe Journal of dermatology2026
Mycosis Fungoides Is a Proliferation of Multiple Mutational Subclones.
Review in The Journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Mycosis fungoides (MF) is a unique type of lymphoma with an excellent prognosis presenting with a wide variety of clinical and histological findings. Recent sophisticated research techniques have revealed that very slow changes in the clinical and histological pictures of one patient over time are due to intratumoral heterogeneity. This means the distribution of different subclones into individual skin lesions and the accumulation of genomic and epigenomic changes in known pathways, starting from immature T-cell precursors. MF is now recognized as the proliferation of multiple mutational subclones that originate from immature T-cell precursors with malignant potential. This may explain why there are so many case reports of MF accompanied by T-cell lymphoproliferative disorders or cutaneous T-cell lymphomas. In addition, the distinction between "transformation" and "complication" of MF may depend on where the disease branches in the T-cell lineage development and the extent of the disease entity defined by MF.
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