Evidence map›Paper›PMID 41589677›Full record

ArticleeLife2026

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors.

Abdulkadir Ozkan, Hari K Padmanabhan, Seth L Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, A Nazli Basak, Jeffrey D Macklis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Abdulkadir Ozkan *Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0003-2499-7637
Hari K Padmanabhan *Department of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0002-2289-0249
Seth L ShipmanDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.
Eiman AzimDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0002-1015-1772
Priyanka KumarDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.
Cameron SadeghDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.
A Nazli BasakKoç University, School of Medicine Translational Medicine Research Center, Istanbul, Turkiye.
Jeffrey D MacklisDepartment of Stem Cell and Regenerative Biology, and Center for Brain Science, Harvard University, Cambridge, United States.ORCID https://orcid.org/0000-0003-3662-9698

Funding

Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and RegenerationDP1NS106665 · NINDS · HARVARD UNIVERSITY · PI MACKLIS, JEFFREY D · 2017 to 2021
$5.9M
Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Cortico-Spinal Repopulation from Precursors for RepairR01NS049553 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2004 to 2007
$1.6M
McKnight Brain Research Institute Regeneration Project FellowshipNINDS NIH HHS DP1 NS106665NINDS NIH HHS NS045523NINDS NIH HHS NS049553NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS049553
6 · The paper itself

Abstract

Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) results from damage to CSN axons. For functional regeneration of specifically affected neuronal circuitry

Indexed as

Cell DifferentiationCerebral CortexNeural Stem CellsNeuronsProteoglycansPyramidal TractsSOXD Transcription FactorsAnimalsBasic Helix-Loop-Helix ProteinsChondroitin Sulfate Proteoglycan 4MiceNerve Tissue ProteinsNeurogenesisBasic Helix-Loop-Helix ProteinsChondroitin Sulfate Proteoglycan 4Nerve Tissue ProteinsNeurog2 protein, mouseProteoglycansSox6 protein, mouseSOXD Transcription Factorscircuit repaircorticospinal neuronsCSNdirected differentiationdisease modelingmouseneuron regenerationneuroscienceregenerative medicineSOX6+/NG2+ progenitorsstem cells

Identifiers

PMID41589677
PMCPMC12844902

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.