ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission.
Abstract read
In one paragraph
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Efficient, Capsule-Free Nymphal Ixodid Tick Placement for Site-Specific Attachment to Assess Anti-Tick Host Behavior and Immune Responses.Current protocols · 2026Article
- Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An Integrative Framework Identifies Cooperative Targeting of Host Pathways by Tick Salivary miRNAs.Computational and structural biotechnology journal · 2026Article
Corrections and comments
- Update of
Authors and funding
28 authors.
Johannes S P DoehlVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0001-9374-6706
Tiago D SerafimVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-1606-559X
Serena DohVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0009-0003-8324-5475
Charles S GruganVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-2892-2846
Eva IniguezVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0009-0006-9027-0523
Luana RogerioVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-0136-7413
Ronja FrigardVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-8086-6394
Ranadhir DeyLaboratory of Emerging Pathogens (LEP), Division of Emerging and Transfusion Transmitted Diseases (DETTD), Office of Blood Research and Review (OBRR), Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, Maryland, USA.ORCID https://orcid.org/0000-0003-0069-7867
Pedro CecilioVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0001-5945-5040
Xinglong GuMolecular Genetics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-0437-5606
Pang-Yen TsengMolecular Genetics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-2039-0002
Aline da Silva MoreiraVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-5907-4261
Mahnaz MinaiInfectious Disease and Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-4610-4863
James OristianVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0009-0006-5225-8996
Hans AckermanPhysiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-4940-3305
Steven BrooksPhysiology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0001-7357-1419
Caroline PercopoLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-1497-8128
Siu-Ping NgLyme Disease Studies Unit, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0009-0008-9919-4613
Derron A AlvesInfectious Disease and Pathogenesis Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0009-0003-5993-182X
Lucas TirloniTick-Pathogen Transmission Unit, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana, USA.ORCID https://orcid.org/0000-0003-4582-7100
Jennifer M AndersonVaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Adriana MarquesLyme Disease Studies Unit, Laboratory of Clinical Immunology & Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-5403-4551
Fabiano OliveiraVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-7924-8038
Shaden KamhawiVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0003-4304-636X
Daniel E SonenshineVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0001-9370-918X
José M C RibeiroVector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-9107-0818
Mark HoonMolecular Genetics Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-8794-1684
Jesus G ValenzuelaVector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA.ORCID https://orcid.org/0000-0002-5589-9450
Funding
Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID)NIDCR NIH HHSNIH HHS
Abstract
Acquired tick resistance (ATR) is well characterized in tick-exposed animals, compromising tick fitness through antibody-mediated activation of basophils. Yet, anti-tick vaccines inducing ATR have had limited success. Here, we describe a neuroimmune event preceding ATR that leads to rapid host-mediated tick removal. Tick-sensitized guinea pigs mechanically remove ticks within 3-6 h via an acquired neuroimmune-induced itch response that correlates with increased dermal expression of itch-associated genes and skin infiltration by CD3
Indexed as
Adaptive ImmunityNeuroimmunomodulationPruritusTick BitesTicksAnimalsGuinea Pigsadaptive immunityectoparasiteitchneuroimmune responsetick removalticks
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.