Biocompatibility and Drug Release Properties of Carboxymethyl Cellulose Hydrogel for Carboplatin Delivery.

Hiroyuki Kono, Shion Kinjyo, Ryou Uyama, Sayaka Fujita, Yuko Murayama, Shinya Ikematsu

Abstract read

In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Preclinical Histologic and Morphometric Comparison of Poly-L-Lactic Acid Fillers Formulated With Carboxymethyl Cellulose or Non-crosslinked Hyaluronic Acid in a Porcine Model.Cureus · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hiroyuki KonoDivision of Applied chemistry and Biochemistry, National Institute of Technology, Tomakomai College, Nishikioka 443, Tomakomai 059-1275, Japan.ORCID 0000-0001-5675-3157

Shion KinjyoDepartment of Bioresources Engineering, National Institute of Technology, Okinawa College, Henoko 905, Nago 905-2192, Japan.

Ryou UyamaDivision of Applied chemistry and Biochemistry, National Institute of Technology, Tomakomai College, Nishikioka 443, Tomakomai 059-1275, Japan.

Sayaka FujitaDivision of Applied chemistry and Biochemistry, National Institute of Technology, Tomakomai College, Nishikioka 443, Tomakomai 059-1275, Japan.

Yuko MurayamaDepartment of Bioresources Engineering, National Institute of Technology, Okinawa College, Henoko 905, Nago 905-2192, Japan.

Shinya IkematsuDepartment of Bioresources Engineering, National Institute of Technology, Okinawa College, Henoko 905, Nago 905-2192, Japan.

Funding

Japan Science and Technology Agency JPMJSA2206Japan Society for the Promotion of Science JP24K08548Japan Society for the Promotion of Science JP25K03365

6 · The paper itself

Abstract

Carboxymethylcellulose (CMC) is a biocompatible and biodegradable polysaccharide suitable for biomedical applications. Herein, an epichlorohydrin (ECH)-crosslinked CMC hydrogel (CMCG) was developed as a carrier for sustained drug release. Ether-type crosslinking between the hydroxyl groups of CMC and ECH yielded a transparent, highly water-absorbent gel. Structural analyses employing Fourier-transform infrared and solid-state

Indexed as

biocompatibilitycarboplatincarboxymethylcellulosecell culturecolorectal cancer cellscontrolled releasedrug delivery systemhydrogelin vivo studysafety evaluation

Identifiers

PMID41590031

DOI10.3390/gels12010005

PMCPMC12840700

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.