Evidence map›Paper›PMID 41590168›Full record

ReviewDentistry journal2026

The Role of Oxidative Stress and Total Antioxidant Capacity in the Management of Impacted Third Molars: A Narrative Review.

Isis Mateos-Corral, Rogelio González-González, Marcelo Gómez Palacio-Gastelum, Ronell Bologna-Molina, Sandra López-Verdín, Omar Tremillo-Maldonado, Victor H Toral-Rizo, Nicolás Serafín-Higuera

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dentistry journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isis Mateos-CorralDepartment of Oral Surgery, School of Dentistry, Autonomous University of Baja California, Mexicali 21040, Mexico.ORCID 0000-0003-2520-9794
Rogelio González-GonzálezResearch Department, School of Dentistry, Juarez University of the Durango State, Durango 34000, Mexico.ORCID 0000-0003-4457-704X
Marcelo Gómez Palacio-GastelumResearch Department, School of Dentistry, Juarez University of the Durango State, Durango 34000, Mexico.ORCID 0000-0002-3384-3202
Ronell Bologna-MolinaResearch Department, School of Dentistry, Juarez University of the Durango State, Durango 34000, Mexico.ORCID 0000-0001-9755-4779
Sandra López-VerdínComprehensive Dental Clinics Department, Research Institute of Dentistry, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Mexico.ORCID 0000-0002-8397-1720
Omar Tremillo-MaldonadoResearch Department, School of Dentistry, Juarez University of the Durango State, Durango 34000, Mexico.ORCID 0000-0002-2798-1596
Victor H Toral-RizoOrocenter Clinic, Faculty of Dentistry, Autonomous University of the State of Mexico, Toluca de Lerdo 50130, Mexico.
Nicolás Serafín-HigueraCellular Biology Laboratory, Health Sciences Center, Dentistry School, Autonomous University of Baja California, Mexicali 21040, Mexico.ORCID 0000-0002-0402-3985

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress (OS) has gained substantial relevance due to its involvement in the pathogenesis of numerous systemic diseases. It is characterized by an imbalance between the production of reactive oxygen species (ROS) and the capacity of endogenous antioxidant systems to neutralize them. Various factors, including trauma, immunological alterations, and psychological stress, may contribute to this condition. The aim of this narrative review was to analyze OS markers and total antioxidant capacity (TAC) in asymptomatic and pericoronitis-associated impacted mandibular third molars (ITMs). This review examines the relationship between OS and impacted ITMs, highlighting the importance of timely clinical management to prevent chronic tissue damage. Current evidence indicates that OS biomarkers such as myeloperoxidase (MPO), malondialdehyde (MDA), uric acid (UA), and nitric oxide (NO) are elevated in patients with ITMs, including those classified as asymptomatic, and that a reduction in total antioxidant capacity (TAC) has been observed. The surgical removal of ITMs can effectively reduce OS levels. Following the procedure, oxidative markers typically return to normal within a relatively short period of time, and there is often a significant improvement in TAC.

Indexed as

biomarkersimpacted third molaroxidative stressreactive oxygen speciesthird molar surgerytotal antioxidant capacity

Identifiers

PMID41590168
PMCPMC12839831

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.