ArticleMarine drugs2025
Fine-Tuning Side Chain Substitutions: Impacts on the Lipophilicity-Solubility-Permeability Interplay in Macrocyclic Peptides.
Yangping Deng, Hengwei Bian, Hongbo Li, Yingjun Cui, Sizheng Li, Jing Li, Li Chen, Xuemei Zhang, Zhuo Shen, Fengyue Li and 2 more
Abstract read
In one paragraphArticle in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Yangping DengState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.ORCID 0000-0002-3664-0427 Hengwei BianState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Hongbo LiAccendatech Company, Ltd., Tianjin 300193, China.
Yingjun CuiAccendatech Company, Ltd., Tianjin 300193, China.
Sizheng LiState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Jing LiState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.
Li ChenState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.ORCID 0000-0001-8820-1496 Xuemei ZhangAccendatech Company, Ltd., Tianjin 300193, China.
Zhuo ShenAccendatech Company, Ltd., Tianjin 300193, China.
Fengyue LiAccendatech Company, Ltd., Tianjin 300193, China.
Yue ChenState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.ORCID 0000-0002-1317-7097 Haohao FuState Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.ORCID 0000-0003-0908-0046 Funding
National Natural Science Foundation of China 22293030National Natural Science Foundation of China 22293032National Natural Science Foundation of China 22473062National Natural Science Foundation of China 82273794Natural Science Foundation of Tianjin 23JCQNJC01420
6 · The paper itselfAbstract
Macrocyclic drugs are promising for targeting undruggable proteins, including those in cancer. Our prior work identified BE-43547A
Indexed as
Antineoplastic AgentsMacrocyclic CompoundsPeptides, CyclicCaco-2 CellsClick ChemistryHumansHydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationPermeabilitySolubilityStructure-Activity RelationshipAntineoplastic AgentsMacrocyclic CompoundsPeptides, Cyclicclick reactionfree-energy calculationlipophilicitymacrocyclic ligandsmembrane permeabilitysolubility
Identifiers
PMID41590710
PMCPMC12843137
What Socratic holds
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