ReviewJournal of cardiovascular development and disease2026
Precision Profiling of the Cardiovascular Post-Translationally Modified Proteome.
Review in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins exist as multiple chemical and sequence-specific proteoforms, each of which may serve as a critical mediator of physiological or pathological signalling. This diversity arises from processes such as alternative splicing of gene transcripts, translation into amino acid sequences, and various post-translational modifications (PTMs), leading to an exponential increase in biological complexity. This manuscript provides an overview of the mechanisms underlying proteoform generation in biological systems and highlights strategies for their analysis using mass spectrometry (MS)-based proteomics and bioinformatics. Additionally, it focuses on recent findings linking PTMs to cardiovascular disease (CVD), highlighting the MS-based methods and workflows that have been used to study uncommon PTMs and their role in CVD. This review provides a comprehensive collection of tools and knowledge to explore the breadth of proteoforms, particularly PTMs, within their specific areas of interest in cardiovascular physiology.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.