Evidence map›Paper›PMID 41591228›Full record

ArticleTropical medicine and infectious disease2026

The Effect of Artemether-Lumefantrine Combined with a Single Dose of Primaquine on

Awoke Minwuyelet, Delenasaw Yewhalaw, Giulio Petronio Petronio, Roberto Di Marco, Getnet Atenafu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Awoke MinwuyeletDepartment of Biology, College of Natural and Computational Science, Debre Markos University, Debre Markos P.O. Box 269, Ethiopia.ORCID 0000-0003-2612-9884
Delenasaw YewhalawTropical and Infectious Diseases Research Center, Jimma University, Jimma P.O. Box 5195, Ethiopia.
Giulio Petronio PetronioDepartment of Medicine and Health Sciences "Vincenzo Tiberio", Università degli Studi del Molise, 86100 Campobasso, Italy.ORCID 0000-0002-5098-7785
Roberto Di MarcoDepartment of Drug and Health Sciences, Università degli Studi di Catania, 95131 Catania, Italy.ORCID 0000-0001-5075-4597
Getnet AtenafuDepartment of Biology, College of Natural and Computational Science, Debre Markos University, Debre Markos P.O. Box 269, Ethiopia.ORCID 0000-0002-0955-6211

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria remains a major public health concern in Africa, due to the persistence of

methodsA prospective cohort and entomological study were conducted from January to September 2025 in Northwest Ethiopia. Ninety-six microscopically confirmed cases of

resultsGametocyte prevalence declined faster with AL + SLD-PQ (15.2% on day 3; 0% by day 7) compared to AL alone (28.9% on day 3:

conclusionsHigh baseline gametocyte density strongly correlated with increased infectivity. Adding SLD-PQ markedly accelerates gametocyte clearance and completely blocks post-treatment transmission. Submicroscopic gametocytemia contributed to residual transmission in the AL-only group. Incorporation of SLD-PQ alongside AL, in line with WHO recommendations, is advised to enhance post-treatment transmission blocking, with continued surveillance.

Indexed as

Anopheles arabiensisartemether-lumefantrinegametocytemiainfectivitymembrane feeding assaysPlasmodium falciparumprimaquine

Identifiers

PMID41591228
PMCPMC12846533

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.