Evidence map›Paper›PMID 41591468›Full record

ArticleCancer immunology, immunotherapy : CII2026

IRAK4 Regulates NF-κB signaling to suppress CD8 + T cell activity and promote immune evasion in glioblastoma development.

Zhaoliang Xue, Zhengfei Song, Lianjie Mo, Lufeng Shi, Shuxu Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhaoliang XueDepartment of Neurosurgery, SIR Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 QingChun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China.
Zhengfei SongDepartment of Neurosurgery, SIR Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 QingChun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China.
Lianjie MoDepartment of Neurosurgery, SIR Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 QingChun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China.
Lufeng ShiDepartment of Neurosurgery, SIR Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 QingChun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China.
Shuxu YangDepartment of Neurosurgery, SIR Run Run Shaw Hospital, School of Medicine, Zhejiang University, No. 3 QingChun Road East, Hangzhou, 310016, Zhejiang, People's Republic of China. 3195019@zju.edu.cn.

Funding

General Scientific Research Project of Provincial Department of Education Zhejiang Education Office Letter (2023) No. 172
6 · The paper itself

Abstract

Glioblastoma remains a highly aggressive brain tumor characterized by immune evasion, limiting the efficacy of immunotherapies. This study investigates the role of interleukin-1 receptor-associated kinase 4 (IRAK4) in modulating CD8

Indexed as

Brain NeoplasmsCD8-Positive T-LymphocytesGlioblastomaInterleukin-1 Receptor-Associated KinasesNF-kappa BTumor EscapeAnimalsCell Line, TumorHumansMiceSignal TransductionInterleukin-1 Receptor-Associated KinasesIRAK4 protein, humanIrak4 protein, mouseNF-kappa BCD8+ T cellsGlioblastomaImmune evasionIRAK4NF-κB signalingProteomics

Identifiers

PMID41591468
PMCPMC12847524

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.