ArticleCell and tissue research2026
Rab24 protein levels show dynamic changes in mouse tissues and human cancers.
Article in Cell and tissue research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Rab24 is an unusual member of the Rab family of small GTPases, implicated in autophagy, endocytosis and cell division. In order to elucidate possible organ and age-specific roles of Rab24, we investigated tissue-specific levels of Rab24 in mice by western blotting and immunohistochemistry from postnatal day one to 9 months of age. In adult mice, the highest protein levels were found in the brain followed by the kidney, whereas lower levels were detected in the pancreas, spleen, liver, lung, heart, and skeletal muscle. Dynamic changes in Rab24 levels were observed during early postnatal development, with a sharp increase in the brain at postnatal day 14, after which the level remained high into adulthood. In the heart, skeletal muscle, pancreas and liver, higher Rab24 levels were observed during the first two postnatal weeks, after which the levels dropped and stayed low until adulthood. The age-dependent changes suggest age- and organ-specific regulation of Rab24 protein levels and possible organ-specific roles for Rab24 in development and maturation. Immunohistochemistry of the brain revealed that Rab24 was mostly present in neuronal cells in 1-month-old and older mice. Also, epithelial cells in several tissues showed high Rab24 levels. These results suggest possible roles for Rab24 in neuronal and epithelial maintenance. We further analysed immunohistochemical staining for RAB24 in human cancers and normal tissues. RAB24 staining in cancers of the breast and skin was higher than in the corresponding normal tissues, while it was reduced in cancers of the digestive system and the urinary tract. We also observed elevated RAB24 staining in medulloblastoma and neuroblastoma, two paediatric cancers of neuronal origin. In pancreatic neuroendocrine tumours that originate from islet cells, RAB24 levels were lower than in normal pancreatic islet cells. Collectively, our findings provide a comprehensive overview of RAB24 protein levels across mouse tissues and a wide spectrum of human cancers. The observed differences in RAB24 levels between cancer types and between malignant and normal tissues, suggest that RAB24 may serve as a potential diagnostic or differentiation marker in specific tumour types.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.