Evidence map›Paper›PMID 41591710›Full record

ArticleMolecular neurobiology2026

Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits.

Marawan Elbaset, Reem El Jammal, Naazneen Khan, I-Ju Yeh, Aidan Looney, Tyler Nguyen, Mohammed H Al-Juboori, Gabriel T Flath-Everhard, Susan Conrad, Sergiu Abramovici and 4 more

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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marawan ElbasetStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Reem El JammalStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Naazneen KhanStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
I-Ju YehStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Aidan LooneyStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Tyler NguyenStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Mohammed H Al-JubooriStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Gabriel T Flath-EverhardStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Susan ConradDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Sergiu AbramoviciDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Ken YoshidaDepartment of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
Adrian L OblakStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Fletcher A WhiteStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-8408-9262
Makram ObeidStark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. makobeid@iu.edu.ORCID http://orcid.org/0000-0003-4349-674X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long-term effects of non-convulsive status epilepticus (NCSE) and their mechanisms in the brain remain largely unknown. Such insight is needed to better shape the clinical approach to this condition. Here, we investigated long-term alterations in hippocampal transcriptomic profiles following an episode of limbic NCSE in periadolescent rats. Cortical and hippocampal mRNA expressions were measured 2 months following intrahippocampal kainic acid (NCSE group, n = 3) or saline injections (controls, n = 4). Compared to controls, NCSE-treated rodents exhibited a significant twofold downregulation in 126 genes in the CA1 hippocampal subfield, 11 in the CA2-3 region, and 21 in the dentate/hilar areas. Most of the identified genes are known to play an essential role in learning and hippocampal plasticity. Additional roles include modulation of inflammatory responses. Twenty altered genes are known to contribute to human intellectual and mental disease pathology, and nine out of these are direct causes of cognitive and neurodevelopmental brain disorders. Spatial deconvolution analyses revealed NCSE-related increases in CA2-3 microglia and hilar astrocytes coupled with increases in dentate GABAergic neurons. These long-term region-specific cellular and molecular hippocampal alterations may contribute to both inflammatory states and disturbances in neuronal function. Taken together, these gene expression changes are suggestive of neuroinflammation-driven synaptic dysfunction following NCSE.

Indexed as

Cognition DisordersHippocampusInflammationLimbic SystemStatus EpilepticusTranscriptomeAnimalsAstrocytesGABAergic NeuronsKainic AcidMaleMicrogliaRats, Sprague-DawleyRNA, MessengerSpatial TranscriptomicsKainic AcidRNA, MessengerAdolescentCognitionHippocampusMessenger RNANon-convulsive status epilepticusTranscriptomic profile

Identifiers

PMID41591710

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.