Evidence map›Paper›PMID 41591735›Full record

ArticleJournal of endocrinological investigation2026

Sarcopenic obesity increases the risk of falls in early-onset type 2 diabetes.

Xiaoyuan Chen, Yongze Zhang, Biao Zheng, Ximei Shen, Lingning Huang, Fengying Zhao, Sunjie Yan

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In one paragraph

Article in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoyuan ChenDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China.
Yongze ZhangDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China.
Biao ZhengDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China.
Ximei ShenDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China.
Lingning HuangDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China.
Fengying ZhaoDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China.
Sunjie YanDepartment of Endocrinology, the First Affiliated Hospital, Fujian Medical University, 350005, Fuzhou, China. fjyansunjie@163.com.ORCID http://orcid.org/0000-0002-9695-1307

Funding

Major Scientific and Technological Special Project of Guizhou Province No.2021ZD01004National Natural Science Foundation of China 82300984National Natural Science Foundation of China 82371601
6 · The paper itself

Abstract

aimsThis study aimed to investigate the association between early-onset type 2 diabetes (EOT2D) and the risk of falls, focusing on the role of sarcopenic obesity.

methodsA total of 580 patients (290 with EOT2D and 290 with late-onset type 2 diabetes [LOT2D]) were selected through propensity score matching. Participants were categorized into four groups: non-sarcopenia/non-obesity, obesity-only, sarcopenia-only, and sarcopenic obesity. Binary logistic regression models were employed to examine the relationships between age at diabetes onset, sarcopenic obesity, and fall risk. Additionally, 472 patients were followed longitudinally to assess the associations between EOT2D, LOT2D, sarcopenic obesity, and fall risk.

resultsPatients with EOT2D exhibited a higher prevalence of sarcopenic obesity compared to those with LOT2D. EOT2D was significantly associated with an increased risk of falls, both directly and indirectly via sarcopenic obesity (β = 0.81, OR

conclusionsPatients with EOT2D are more prone to developing sarcopenic obesity, and visceral obesity contributes to the elevated risk of falls in this population. Therefore, interventions to preserve muscle mass and strength while reducing visceral fat accumulation are critical in mitigating fall risk among patients with EOT2D.

Indexed as

Accidental FallsDiabetes Mellitus, Type 2ObesitySarcopeniaAgedAge of OnsetFemaleFollow-Up StudiesHumansMaleMiddle AgedPrevalencePrognosisRisk FactorsEarly-onset diabetesFall riskObesitySarcopeniaSarcopenic obesity

Identifiers

PMID41591735

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.