Evidence map›Paper›PMID 41593213›Full record

SynthesisCurrent allergy and asthma reports2026

Inverted Sinonasal Papilloma: Pheno-endotyping and Predictive Markers of Recurrence and Malignancy - A Systematic Review.

María Paola Aguilera, Daniela Pastene, Joan Lop, Concepció Marin, Joaquim Mullol, Isam Alobid

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Current allergy and asthma reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María Paola AguileraRhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clinic Barcelona, IDIBAPS, CIBERES, University of Barcelona, C. Villarroel 170, 08036, Barcelona, Catalonia, Spain. paola.aguilera1992@gmail.com.
Daniela PasteneRhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clinic Barcelona, IDIBAPS, CIBERES, University of Barcelona, C. Villarroel 170, 08036, Barcelona, Catalonia, Spain.
Joan LopDepartment of Pathological Anatomy, Hospital Clinic Barcelona, IDIBAPS, University of Barcelona, Barcelona, Catalonia, Spain.
Concepció MarinINGENIO, Multidisciplinary and Translational Research in Inflammation and Immunoallergy (METRI2A), FRCB-IDIBAPS, Barcelona, Catalonia, Spain.
Joaquim MullolRhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clinic Barcelona, IDIBAPS, CIBERES, University of Barcelona, C. Villarroel 170, 08036, Barcelona, Catalonia, Spain.
Isam AlobidRhinology and Skull Base Unit, Department of Otorhinolaryngology, Hospital Clinic Barcelona, IDIBAPS, CIBERES, University of Barcelona, C. Villarroel 170, 08036, Barcelona, Catalonia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review aimed to summarize the inflammatory, microscopic, and histopathological features of inverted sinonasal papilloma (ISP) and to identify viral, molecular, and genetic predictors of recurrence and malignant transformation. RECENT

findingsRecent studies describe a heterogeneous inflammatory microenvironment with mixed Th1/Th2/Th17 cytokine responses and epithelial neutrophilia as a defining hallmark. Considerable variability persists across studies evaluating viral and molecular markers. High-risk Human Papillomavirus type 18 (HR-HPV-18), Epidermal Growth Factor Receptor (EGFR) exon 20 mutations, p53 alterations, and p16 loss have been most consistently linked to recurrence and malignant progression. SNIP exhibits multifactorial biological behavior driven by inflammation, viral infection, and molecular dysregulation. These findings highlight the need for standardized histopathological and molecular criteria and prospective studies to refine recurrence prediction and early detection of malignant transformation.

Indexed as

Neoplasm Recurrence, LocalPapilloma, InvertedPapillomavirus InfectionsParanasal Sinus NeoplasmsBiomarkers, TumorHuman papillomavirus 18HumansPrognosisBiomarkers, TumorBiomarkersInflammationInverted sinonasal papillomaMalignant transformationRecurrenceSquamous cell carcinoma

Identifiers

PMID41593213

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.