Evidence map›Paper›PMID 41593700›Full record

ArticleGenome biology2026

Campolina: a deep neural framework for accurate segmentation of nanopore signals.

Sara Bakić, Krešimir Friganović, Bryan Hooi, Mile Šikić

Abstract read
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara BakićGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, 138672, Singapore, Republic of Singapore.
Krešimir FriganovićGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, 138672, Singapore, Republic of Singapore.
Bryan HooiSchool of Computing, National University of Singapore, 13 Computing Drive, 117417, Singapore, Republic of Singapore.
Mile ŠikićGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, 138672, Singapore, Republic of Singapore. mile_sikic@a-star.edu.sg.

Funding

Singapore Ministry of Health's National Medical Research Council NMRC/OFIRG/MOH-000649-00
6 · The paper itself

Abstract

Nanopore sequencing enables real-time, long-read analysis by processing raw signals as they are produced. A key step, segmentation of signals into events, is typically handled algorithmically, struggling in noisy regions. We present Campolina, a first deep-learning framework for accurate segmentation of raw nanopore signals. Campolina uses a convolutional model to identify event boundaries and significantly outperforms the traditional Scrappie algorithm on R9.4.1 and R10.4.1 datasets. We introduce a comprehensive evaluation pipeline and show that Campolina aligns better with reference-guided ground-truth segmentation. We show that integrating Campolina segmentation into real-time frameworks, Sigmoni and RawHash2, improves their performance while maintaining time efficiency.

Indexed as

Deep LearningNanoporesNanopore SequencingSoftwareAlgorithmsDeep learningNanopore sequencingRaw nanopore signalsRaw signal processingReal-time analysisSegmentation

Identifiers

PMID41593700
PMCPMC12918622

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.