Evidence map›Paper›PMID 41594606›Full record

ArticleBiomolecules2025

Intermethod Characterization of Commercially Available Extracellular Vesicles as Reference Materials.

Sumeet Poudel, Diane L Nelson, James H Yen, Yuefan Wang, Hui Zhang, Zhiyong He, Ashley Beasley Green, Wyatt N Veerland, Thomas E Cleveland Iv, Sean E Lehman and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sumeet PoudelNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Diane L NelsonNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
James H YenNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0001-5242-7629
Yuefan WangDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0001-5731-6143
Hui ZhangDepartment of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0001-8726-7098
Zhiyong HeNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0009-0002-4650-2826
Ashley Beasley GreenNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0002-2065-4218
Wyatt N VeerlandNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0003-0524-8403
Thomas E Cleveland IvNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0003-1992-8450
Sean E LehmanNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Kurt D BenksteinNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0002-3474-779X
Bryant C NelsonNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0001-8166-4121
Lili WangNational Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0003-2456-898X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The National Institute of Standards and Technology (NIST) is developing analytical methods to characterize extracellular vesicles (EVs) to support the urgent need for standardized EV reference materials (RMs). This study used orthogonal techniques, cryogenic electron microscopy (Cryo-EM), particle tracking analysis (PTA), asymmetrical flow field-flow fractionation (AF

Indexed as

Extracellular VesiclesCell Line, TumorCryoelectron MicroscopyFractionation, Field FlowHumansMaleMesenchymal Stem CellsMicroRNAsParticle SizeProteomicsReference StandardsMicroRNAsEV characterizationextracellular vesicles (EVs)particle number concentration (PNC)particle size distribution (PSD)reference materials

Identifiers

PMID41594606
PMCPMC12838729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.