ArticleBiomolecules2026
Blood Concentrations of Folic Acid and Homocysteine Are Associated with Treatment-Resistant Depression Among Female Depressed Patients.
Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Treatment-resistant depression (TRD) is a subtype of major depressive disorder (MDD) that fails to respond to first-line pharmacotherapy. This cross-sectional study compared blood concentrations of folic acid, vitamin B12, and homocysteine between female depressed patients with or without TRD, and examined the association of these parameters with the severity of depression. It included 116 female patients treated for MDD, of whom 59 (51%) developed TRD. The diagnosis of MDD was established via a structured clinical interview, while the severity of depression was measured with the Montgomery-Asberg Depression Rating Scale. Blood samples were taken at the initial psychiatric examination to determine the serum levels of folic acid and vitamin B12 and plasma levels of homocysteine. Folic acid levels were significantly lower in the female TRD group (
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