ArticleCancers2026
Adverse Outcome Pathway 298: Increase in Reactive Oxygen Species Leading to Human Treatment-Resistant Gastric Cancer.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Injury causes resistance in human gastric cancer. Adverse Outcome Pathway (AOP) 298, entitled "increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer," consists of "increase in ROS" as a molecular initiating event (MIE), followed by a series of key events (KEs), namely "porcupine-induced Wnt secretion and Wnt signaling activation," "beta-catenin activation," and "epithelial-mesenchymal transition (EMT)," and the adverse outcome (AO) of "treatment-resistant gastric cancer" in the sequence. AOP 298 includes four KE relationships (KERs): "increase in ROS leads to porcupine-induced Wnt secretion and Wnt signaling activation," "porcupine-induced Wnt secretion and Wnt signaling activation leads to beta-catenin activation," "beta-catenin activation leads to EMT," and "EMT leads to treatment-resistant gastric cancer." ROS has multiple roles in disease, such as in the development and progression of cancer, or apoptotic induction, causing anti-tumor effects. Regarding AOP 298, we focus on the role of sustained chronic ROS levels in inducing therapy resistance in human gastric cancer. EMT, induced by Wnt/beta-catenin signaling, demonstrates cancer stem cell-like characteristics in human gastric cancer.
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