ArticleCancers2026
Prognostic Value of Phosphatidylinositol-3 Kinase p110 α Protein Expression in Patients with Stage I-III Invasive Breast Cancer.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe prognostic value of phosphatidylinositol-3-kinase p110α, a key catalytic subunit in the PI3K/AKT pathway, in breast cancer remains controversial. This study evaluated its prognostic significance in stage I-III invasive breast cancer.
methodsp110α protein expression was detected via immunohistochemistry (IHC) in 161 patient tissue samples. Its association with overall survival (OS) and relapse-free survival (RFS) was analyzed using Kaplan-Meier and Cox proportional hazards models.
resultsp110α positivity was detected in 59.0% of specimens and showed significant correlation with histological grade (
conclusionsp110α protein expression is an independent biomarker for adverse outcomes in stage I-III invasive breast cancer. Its assessment could improve prognostic evaluation and guide personalized therapy.
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