Evidence map›Paper›PMID 41595261›Full record

ReviewCancers2026

Fitness in CLL.

Claudia Baratè, Ilaria Scortechini, Sara Ciofini, Paola Picardi, Ilaria Angeletti, Federica Loscocco, Alessandro Sanna, Alessandro Isidori, Elisa Grazioli, Paolo Sportoletti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Claudia BaratèDepartment of Hematology, Niguarda Cancer Center, ASST Grande Ospedale Metropolitano Niguarda, 20161 Milano, Italy.ORCID 0000-0003-1006-2400
Ilaria ScortechiniClinic of Hematology, Azienda Ospedaliero Universitaria delle Marche, 60126 Ancona, Italy.
Sara CiofiniDepartment of Cell Therapies, Hematology Unit, Senese Hospital and University, 53100 Siena, Italy.
Paola PicardiDepartment of Hematology and Cellular Therapy, Mazzoni Hospital, 63100 Ascoli Piceno, Italy.
Ilaria AngelettiDepartment of Onco-Hematology, Terni Hospital, 05100 Terni, Italy.
Federica LoscoccoHematology and Stem Cell Transplant Center, AST Pesaro and Urbino, 61121 Pesaro, Italy.
Alessandro SannaHematology Unit, AOU Careggi, 50134 Firenze, Italy.ORCID 0000-0002-5015-381X
Alessandro IsidoriHematology and Stem Cell Transplant Center, AST Pesaro and Urbino, 61121 Pesaro, Italy.
Elisa GrazioliUnit of Physical Exercise and Sport Sciences, Department of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Roma, Italy.ORCID 0000-0003-4245-1320
Paolo SportolettiDepartment of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06132 Perugia, Italy.ORCID 0000-0002-5630-9862

Funding

Associazione Italiana per la Ricerca sul Cancro IG- 2024 ID 30768
6 · The paper itself

Abstract

The increased complexity of CLL management, driven by the advent of targeted therapies, makes it necessary to redefine the concept of fitness, which until a few years ago was limited to the patient's ability to undergo chemoimmunotherapy. In the current therapeutic landscape, fitness assessment must also consider biological age, comorbidities, and frailty, which have become increasingly relevant due to evolving treatment options and a more nuanced understanding of the elderly CLL population. In this context, the general condition of the patient should be preserved with greater attention to physical activity and nutrition. This narrative review analyzed in depth all these aspects with the aim of providing insights into fitness assessments and their actualization.

Indexed as

biological agechronic lymphocytic leukemiacomorbiditiesfitnessnutritionphysical activity

Identifiers

PMID41595261
PMCPMC12839421

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.