Evidence map›Paper›PMID 41595449›Full record

ArticleGenes2025

Study on the Regulatory Mechanism of oar-miR-29b in Lamb Encephalitis Caused by

Ming Zhou, Borui Qi, Pengfei Zhao, Longling Jiao, Shuzhu Cao, You Wu, Jingjing Ren, Runze Zhang, Yongjian Li, Yayin Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ming ZhouCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Borui QiCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Pengfei ZhaoCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Longling JiaoCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Shuzhu CaoCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
You WuCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Jingjing RenCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Runze ZhangCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Yongjian LiCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.
Yayin QiCollege of Animal Science & Technology, Shihezi University, Shihezi 832003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsA lamb model of

resultsFunctional studies demonstrated that oar-miR-29b acts as a pro-inflammatory mediator, significantly upregulating IL-1β, IL-6, and TNF-α while degrading tight-junction proteins (ZO-1, occludin, and claudin-5), thereby compromising endothelial barrier integrity. Mechanistically, bioinformatic prediction and dual-luciferase reporter assays confirmed C1QTNF6 as a direct target of oar-miR-29b. The oar-miR-29b/C1QTNF6 axis is thus defined as a novel regulatory pathway contributing to neuro-inflammation and blood-brain barrier disruption.

conclusionsCollectively, our findings identify the oar-miR-29b/C1QTNF6 axis as a novel pathogenic mechanism that exacerbates

Indexed as

EncephalitisEnterococcus faecalisGram-Positive Bacterial InfectionsMicroRNAsAnimalsDisease Models, AnimalGene Expression RegulationLipopolysaccharidesSheepLipopolysaccharidesMicroRNAsEnterococcus faecalisinflammatory injurymicroRNAoar-miR-29btight junction

Identifiers

PMID41595449
PMCPMC12841284

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.