Evidence map›Paper›PMID 41595476›Full record

ReviewGenes2026

Hereditary Polyneuropathies in the Era of Precision Medicine: Genetic Complexity and Emerging Strategies.

Maria Chrysostomaki, Despoina Chatzi, Stella Aikaterini Kyriakoudi, Soultana Meditskou, Maria Eleni Manthou, Sofia Gargani, Paschalis Theotokis, Iasonas Dermitzakis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria ChrysostomakiDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0002-6749-8379
Despoina ChatziDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0008-2200-392X
Stella Aikaterini KyriakoudiDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0002-8622-9318
Soultana MeditskouDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-7929-9110
Maria Eleni ManthouDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-7075-878X
Sofia GarganiDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-4280-0933
Paschalis TheotokisDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8607-6695
Iasonas DermitzakisDepartment of Histology-Embryology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-9134-1083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hereditary polyneuropathies represent a genetically and clinically heterogeneous group of disorders affecting the peripheral nervous system, characterized by progressive motor, sensory, and autonomic impairment. Advances in molecular genetics have identified key causative genes, including

Indexed as

PolyneuropathiesPrecision MedicineCharcot-Marie-Tooth DiseaseConnexinsEarly Growth Response Protein 2Gap Junction beta-1 ProteinGene EditingGenetic TherapyGTP PhosphohydrolasesHumansMitochondrial ProteinsMutationMyelin P0 ProteinMyelin ProteinsConnexinsEarly Growth Response Protein 2EGR2 protein, humanGap Junction beta-1 ProteinGTP PhosphohydrolasesMFN2 protein, humanMitochondrial ProteinsMPZ protein, humanMyelin P0 ProteinMyelin ProteinsPMP22 protein, humangene therapygeneticshereditary polyneuropathiesperipheral nerveprecision medicineSchwann cell

Identifiers

PMID41595476
PMCPMC12841389

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.