Evidence map›Paper›PMID 41595662›Full record

ReviewBiomedicines2026

Directional Modulation of the Integrated Stress Response in Neurodegeneration: A Systematic Review of eIF2B Activators, PERK-Pathway Agents, and ISR Prolongers.

Isabella Ionela Stoian, Daciana Nistor, Mihaela Codrina Levai, Daian Ionel Popa, Roxana Popescu

Abstract readReview
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabella Ionela StoianDoctoral School, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Daciana NistorDepartment of Functional Sciences, Physiology, Centre of Imuno-Physiology and Biotechnologies (CIFBI-OTEH), Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.ORCID 0009-0001-0489-246X
Mihaela Codrina LevaiDoctoral School, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Daian Ionel PopaDoctoral School, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.ORCID 0009-0007-1728-3552
Roxana PopescuDepartment II Microscopic Morphology, Cell and Molecular Biology, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.ORCID 0000-0002-9387-1141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

drug effectsdrug therapyendoplasmic reticulumeukaryotic metabolismneurodegenerative diseasesprotein kinaseprotein response physiology

Identifiers

PMID41595662
PMCPMC12838581

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.