ArticleBioengineering (Basel, Switzerland)2026
Photobiomodulation Modulates the Response of Zoledronic-Acid-Treated Osteoblast-like SaOs-2 Cells: Implications for Bisphosphonate-Related Osteonecrosis.
Rodrigo Antonio Carvalho Andraus, Ana Flávia Spadaccini Silva de Oliveira, Mário Celso Teixeira Lopes, Diego César Marques, Vanessa Gabriela Gonzales Marques, Deise Aparecida de Almeida Pires de Oliveira, Rodrigo Franco de Oliveira, Orlando Aguirres Guedes, Helder Fernandes de Oliveira, João Pedro Ribeiro Afonso and 5 more
Abstract read
In one paragraphArticle in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Rodrigo Antonio Carvalho AndrausGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-3849-0872 Ana Flávia Spadaccini Silva de OliveiraSchool of Physiotherapy, University Center UNIFIO, Ourinhos 19915-501, SP, Brazil.ORCID 0000-0001-9410-9282 Mário Celso Teixeira LopesGraduate Program in Dentistry, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0009-0002-7629-5995 Diego César MarquesGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0009-0001-9279-1529 Vanessa Gabriela Gonzales MarquesGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0009-0006-2097-1965 Deise Aparecida de Almeida Pires de OliveiraGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-5765-1897 Rodrigo Franco de OliveiraGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-8074-8083 Orlando Aguirres GuedesGraduate Program in Dentistry, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0003-1664-329X Helder Fernandes de OliveiraGraduate Program in Dentistry, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0003-4228-3814 João Pedro Ribeiro AfonsoGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-1392-4910 Iransé Oliveira SilvaGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0003-2692-1548 Luiz Vicente Franco de OliveiraGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-3852-9415 Claudia Santos OliveiraGraduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0009-0000-6453-2039 Regina Célia PoliGraduate Program in Rehabilitation Sciences, University Pitagoras UNOPAR, Londrina 86041-140, PR, Brazil.ORCID 0000-0003-4631-4606 Luciana Prado MaiaGraduate Program in Dentistry, Evangelical University of Goias (UniEVANGÉLICA), Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-5697-2587 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
This study aimed to evaluate the effects of laser photobiomodulation (PBM) therapy in SaOs-2 osteosarcoma cells treated with zoledronic acid (ZA), a bisphosphonate, in vitro, mimicking a bisphosphonate-related osteonecrosis of the jaw (BRONJ) situation. Cells were treated with 100 μM ZA for 24 h and subjected to PBM using wavelengths of 660 nm and 808 nm at energy delivered of 1, 5, 10, and 20 J. After 24 h, metabolic activity, apoptosis, and BAX and BCL-2 gene expression were analyzed. Data were compared using one-way ANOVA followed by Tukey's post hoc test (
Indexed as
apoptosisgene expressionlaser therapyosteosarcomaphotobiomodulation
Identifiers
PMID41596019
PMCPMC12838379
What Socratic holds
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