ArticleAntioxidants (Basel, Switzerland)2026
Targeting Arginase 1 but Not Arginase 2 Protects from Myocardial Ischemia-Reperfusion Injury via Nitric Oxide Signaling by Red Blood Cells in Type 2 Diabetes.
Jiangning Yang, Yahor Tratsiakovich, Renhai Cao, Ali Mahdi, Gianluigi Pironti, Tong Jiao, Rawan Humoud, Eftychia Kontidou, John Tengbom, Aida Collado and 5 more
Abstract read
In one paragraphArticle in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
15 authors.
Jiangning YangDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0001-5455-1447 Yahor TratsiakovichDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
Renhai CaoCenter for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden.
Ali MahdiDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0003-0386-7817 Gianluigi PirontiDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
Tong JiaoDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
Rawan HumoudDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0009-0001-6139-3915 Eftychia KontidouDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
John TengbomDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0003-3608-160X Aida ColladoDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
Zhichao ZhouDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-5107-6529 Yihai CaoDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
Eleonore KöhlerDepartment of Anatomy and Embryology, Maastricht University, 6200 MD Maastricht, The Netherlands.ORCID 0000-0003-1977-9977 Adam E MullickIonis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.
John PernowDepartment of Medicine, Unit of Cardiology, Karolinska Institutet, 17177 Stockholm, Sweden.
Funding
Åke Wiberg Foundation M25-0045 to ACKnut and Alice Wallenberg Foundation to JPthe EFSD/Novo Nordisk Foundation Future Leaders Award NNF22SA0081227 to ZZthe Foundation for Geriatric Diseases Karolinska Institutet 2023-01860 to ACThe Foundation for Geriatric Diseases Karolinska Institutet 2025-01921 to ACthe Karolinska Institutet grant (202201767 and 202402867 to ZZ; 202402554 to TJ; 202402459 to ACthe Karolinska Institutet KID grant 202100275 and 202301281 to ZZthe Lars Hierta's Memory Foundation FO2023-0446 to ACthe Stockholm County Council ALF FoUI-972326 to JP; 988725 to AMthe Swedish Heart and Lung Foundation 20200326, 20220264, 20230386 and 20240072 to ZZ; 20220210 and 20250501 to JP; 20241007 to AMThe Swedish Heart and Lung Foundation 20250728 to ACthe Swedish Research Council 2023-02508 to ZZ and 2024-02534 to JPTore Nilson's Foundation for Medical Research 2024-227 to AC
6 · The paper itselfAbstract
backgroundArginase influences cardiac tolerance to ischemia-reperfusion by modulating nitric oxide (NO) signaling. In type 2 diabetes (T2D), elevated arginase activity may worsen ischemic injury through red blood cells (RBCs), but the specific roles of arginase isoforms are unclear.
methodsC57BL/6 and db/db mice were pretreated with
results
conclusionsArginase 1, but not arginase 2, limits cardiac tolerance to ischemia-reperfusion and contributes to increased vulnerability in T2D.
Indexed as
arginaseischemic tolerancenitric oxidesextype 2 diabetes
Identifiers
PMID41596116
PMCPMC12837884
What Socratic holds
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