Evidence map›Paper›PMID 41596188›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Myeloperoxidase (MPO) Enzymatic Activity, but Not Its Protein Concentration, Is Associated with the Risk of Type 2 Diabetes in Females, Regardless of Obesity Status.

Alessandro Trentini, Raffaella Riccetti, Domenico Sergi, Juana Maria Sanz, Riccardo Spaggiari, Valentina Rosta, Gianmarco Mola, Angelina Passaro, MEDIA HDL Research Group, Carlo Cervellati

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro TrentiniDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-3579-7921
Raffaella RiccettiDepartment of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
Domenico SergiDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-3001-410X
Juana Maria SanzDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-3372-2758
Riccardo SpaggiariDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0001-6069-7514
Valentina RostaDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
Gianmarco MolaDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
Angelina PassaroDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
MEDIA HDL Research Group
Carlo CervellatiDepartment of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-4777-6300

Funding

University of Ferrara FAR
6 · The paper itself

Abstract

To date, neutrophil-derived myeloperoxidase (MPO), a key mediator of inflammation and oxidative stress, has predominantly been assessed in peripheral fluids by protein concentration rather than enzymatic activity, mainly due to methodological limitations. However, MPO activity directly reflects the enzyme's cytotoxic potential and pathogenic role in inflammatory diseases. To address this gap, we employed an optimized immunocapture assay to evaluate MPO activity, specific activity, and protein concentration in females with type 2 diabetes mellitus (T2DM), a condition tightly linked to chronic low-grade inflammation and obesity. Our findings revealed that females with T2DM exhibited nearly three-fold higher serum MPO activity and more than two-fold greater specific activity compared to controls with no differences in MPO protein concentration. Notably, MPO-specific activity remained significantly associated with T2DM (

Indexed as

femalesmyeloperoxidase enzymatic activityneutrophil-derived myeloperoxidaseobesitytype 2 diabetes mellitus

Identifiers

PMID41596188
PMCPMC12837212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.