ArticleInternational journal of molecular sciences2026
Gigantol Preserves Lens Biophysical Homeostasis by Restoring Cytoskeletal Integrity and Membrane Fluidity in a Diabetic Cataract Model.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic cataract (DC) is a major complication of diabetes, with human lens epithelial cells (HLECs) playing a central role in its pathogenesis. Gigantol, a natural compound, has demonstrated protective effects against HLEC damage, yet its underlying mechanisms, particularly concerning cellular biophysical properties, remain poorly understood. This study investigated the protective role of gigantol against high-glucose-induced damage in HLECs, with a specific focus on alterations in cellular biophysical properties. Using a multi-technique approach including transmission electron microscopy (TEM), atomic force microscopy, laser scanning confocal microscopy, and Raman spectroscopy, we analyzed changes in ultrastructure, morphology, stiffness, roughness, membrane fluidity, and cytoskeletal organization. Treatment with gigantol effectively restored cellular ultrastructure, mitigated cytoskeletal disruption, and normalized key biomechanical properties: it reduced cell stiffness and roughness by approximately one-fourth, increased cell height by nearly onefold, and enhanced membrane fluidity by one-fifth. Raman spectroscopy indicated that gigantol improved membrane fluidity by modulating lipid bilayer structure, specifically through alterations in -CH
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