Evidence map›Paper›PMID 41596234›Full record

ArticleInternational journal of molecular sciences2026

Rational Design, Synthesis and Pharmacological Evaluation of Chalcones as Dual-Acting Compounds-Histamine H

Dorota Łażewska, Agata Doroz-Płonka, Kamil Kuder, Agata Siwek, Waldemar Wagner, Joanna Karnafał-Ziembla, Agnieszka Olejarz-Maciej, Małgorzata Wolak, Monika Głuch-Lutwin, Barbara Mordyl and 6 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dorota ŁażewskaDepartment of Chemical Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0001-8454-4440
Agata Doroz-PłonkaDepartment of Chemical Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Kamil KuderDepartment of Chemical Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0003-3077-5539
Agata SiwekDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Waldemar WagnerDepartment of Hormone Biochemistry, Faculty of Medicine, Medical University of Łódź, Żeligowskiego 7/9, 90-752 Łódź, Poland.ORCID 0000-0003-1286-8360
Joanna Karnafał-ZiemblaPharmacokinetics and Preliminary Toxicological Analysis Laboratory, Center for the Development of Therapies for Civilization and Age-Related Diseases, Jagiellonian University Medical College in Kraków, Medyczna 7A, 30-688 Kraków, Poland.
Agnieszka Olejarz-MaciejDepartment of Chemical Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0002-1466-0742
Małgorzata WolakDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Monika Głuch-LutwinDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Barbara MordylDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Oktawia OsieckaDepartment of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Michał JuszczakDepartment of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland.
Katarzyna WoźniakDepartment of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland.ORCID 0000-0001-6666-7973
Małgorzata WięcekDepartment of Chemical Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.
Gniewomir LataczDepartment of Chemical Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688 Kraków, Poland.ORCID 0000-0001-9247-2598
Anna StasiakDepartment of Hormone Biochemistry, Faculty of Medicine, Medical University of Łódź, Żeligowskiego 7/9, 90-752 Łódź, Poland.ORCID 0000-0002-2225-7312

Funding

Jagiellonian University Medical College in Kraków N42/DBS/000385Statutory activity of Medical University of Lodz 503/1-156-06/503-11-001the Priority Research Area qLIFE under the Strategic Programme Excellence Initiative at Jagiellonian University U1C/P04/NO/02.26
6 · The paper itself

Abstract

Chalcone-based derivatives were designed as dual-acting ligands targeting the histamine H

Indexed as

ChalconesDrug DesignMonoamine OxidaseMonoamine Oxidase InhibitorsReceptors, Histamine H3Caco-2 CellsHep G2 CellsHumansLigandsMolecular Docking SimulationStructure-Activity RelationshipChalconesLigandsMonoamine OxidaseMonoamine Oxidase InhibitorsReceptors, Histamine H3chalconesdual-target ligandshistamine H3 receptor ligandsmonoamine oxidase B inhibitorsSPRM kinetic studies

Identifiers

PMID41596234
PMCPMC12840679

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.