Evidence map›Paper›PMID 41596274›Full record

ArticleInternational journal of molecular sciences2026

Hyaluronic Acid-Palmitate Nanoparticle Delivery of Carbonic Anhydrase Inhibitors Impairs Growth and Early Metabolism in

Viviana De Luca, Valentina Verdoliva, Claudiu T Supuran, Stefania De Luca, Clemente Capasso

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Viviana De LucaDepartment of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Via P. Castellino, 111, 80131 Naples, Italy.ORCID 0000-0003-3406-833X
Valentina VerdolivaDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, National Research Council (CNR), Institute of Crystallography, Via Vivaldi, 43, 81100 Caserta, Italy.ORCID 0000-0003-4689-7856
Claudiu T SupuranNeurofarba Department, Section of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0003-4262-0323
Stefania De LucaDepartment of Biomedical Sciences, Institute of Biostructures and Bioimaging, National Research Council (CNR), Via P. Castellino, 111, 80131 Naples, Italy.ORCID 0000-0002-7078-1696
Clemente CapassoDepartment of Biology, Agriculture and Food Sciences, National Research Council (CNR), Institute of Biosciences and Bioresources, Via P. Castellino, 111, 80131 Naples, Italy.ORCID 0000-0003-3314-2411

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial carbonic anhydrases (CAs) are essential for intracellular pH regulation, bicarbonate homeostasis, and energy metabolism, making them attractive antimicrobial targets. Here, building on evidence that acetazolamide (AZA) delivered via hyaluronic acid-palmitate (HA-PA) nanocarriers impairs

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesEscherichia coliHyaluronic AcidNanoparticlesAcetazolamideAdenosine TriphosphateGlucoseAcetazolamideAdenosine TriphosphateCarbonic Anhydrase InhibitorsCarbonic AnhydrasesGlucoseHyaluronic Acidbacterial growth inhibitioncarbonic anhydrasecarbonic anhydrase inhibitorsenergy metabolismEscherichia colihyaluronic acid-palmitate nanoparticles

Identifiers

PMID41596274
PMCPMC12841525

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.