Evidence map›Paper›PMID 41596282›Full record

ArticleInternational journal of molecular sciences2026

Transcriptomic Profile of Directed Differentiation of iPSCs into Hepatocyte-like Cells.

Irina Panchuk, Valeriia Kovalskaia, Konstantin Kochergin-Nikitsky, Valentina Yakushina, Natalia Balinova, Oxana Ryzhkova, Alexander Lavrov, Svetlana Smirnikhina

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Irina PanchukResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.ORCID 0000-0002-1323-8638
Valeriia KovalskaiaResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.ORCID 0000-0002-8728-8574
Konstantin Kochergin-NikitskyResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.
Valentina YakushinaResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.ORCID 0000-0001-5236-9297
Natalia BalinovaResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.ORCID 0000-0001-9493-6544
Oxana RyzhkovaResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.ORCID 0000-0003-1285-9093
Alexander LavrovResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.
Svetlana SmirnikhinaResearch Centre for Medical Genetics, Moskvorechye Str., 1, Moscow 115478, Russia.

Funding

This research was supported by the Ministry of Science and Higher Education of the Rusian Federation for RCMG This research was supported by the Ministry of Science and Higher Education of the Russian Federation for RCMG
6 · The paper itself

Abstract

The liver is the central organ in metabolism; however, modeling hepatic diseases remains limited by current experimental models. Animal models frequently fail to predict human liver physiology, while primary hepatocytes rapidly dedifferentiate in culture. We performed comprehensive transcriptomic profiling of induced pluripotent stem cells (iPSCs) differentiation into hepatocyte-like cells (HLCs) under two-dimensional (2D) and three-dimensional (3D) culture conditions. RNA sequencing analysis revealed the sequential activation of lineage-specific markers across major developmental stages: definitive endoderm (

Indexed as

Cell DifferentiationHepatocytesInduced Pluripotent Stem CellsTranscriptomeGene Expression ProfilingHumansLiverOrganoids3D liver organoidsdifferentiationiPSCsRNA-seq

Identifiers

PMID41596282
PMCPMC12840978

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.